摘要
目的:评价H pylori感染的相关因素,为预防决策提供依据.方法:以"幽门螺杆菌"、"感染"、"相关因素"和"流行病学"等为检索词,检索CNKI中国期刊全文数据库及CBM光盘数据库,并辅以文献追溯、手工检索等方法收集1990-01/2008-05国内正式刊物上公开发表的有关H pylori感染相关因素的研究文献.对这些研究中涉及的某些相关因素采用Meta分析方法选择危险比值比OR值作为效应指标进行综合定量分析,估计其合并OR值及其95%CI.根据异质性检验结果选择固定效应模型或随机效应模型进行合并,并从原始文献统计方法采用单因素分析还是多因素分析及变换模型2个角度进行敏感性分析,评价Meta分析结论的稳定性,同时计算失效安全系数来估计发表偏倚的大小.结果:纳入本次Meta分析的文献共21篇,涉及包括来自宿主的因素(性别、本人胃病史)、行为习惯(吸烟、饮酒、饮用水源、饮水习惯、养狗、近期服用抗生素)、饮食习惯(进食生蔬菜、豆类、大蒜、腌制食物、熏制食物)、家人或照顾者胃病史及年幼时是否接受口嚼食物,可能与H pylori感染相关的因素OR值及其95%CI分别为:本人胃病史2.09(1.40,3.12)、看护人胃病史2.43(1.74,3.40)、饮用不洁水源2.01(1.35,3.00)、饮水习惯3.08(1.02,9.26)、养狗1.75(1.02,3.00)、接受过口嚼食物2.66(1.41,5.02)、吸烟1.47(1.09,1.97)、经常食用大蒜0.67(0.56,0.80)、豆类0.37(0.17,0.79)、熏制1.94(1.25,3.02)及腌制食物1.87(1.43,2.44),性别、近期服用抗生素、饮酒、经常食用生蔬菜与H pylori感染无关.结论:在选择的15个因素中,影响我国人群H pylori感染的主要因素为本人胃病史、看护人胃病史、饮用不洁水源、喝生水、养狗、接受过口嚼食物、吸烟、经常食用大蒜、熏制及腌制食物等.
AIM： To evaluate the factors relative to Helicobacter pylori （H pylori） infection using meta- analysis so as to provide evidence for preventing H pylori infection. METHODS： Articles published from 1990 to 2008on the relationship between factors and H pylori infection were searched in CNKI database and CBM database, using the searching terms ＂Helicobacter pylori＂, ＂infection＂, ＂relative factors＂, ＂epidemiology＂, etc. Meanwhile, Relative journals were manually looked up. Chinese literatures about factors relative to H pylori infection were collected and quantitatively analyzed by Meta-analysis, using OR value as the effect index. According to result of test for homogeneity, pooled odds ratio （OR） values and 95% confidence interval （CI） were calculated by choosing a fixed effect model or a random effect model. At the same time, sensitiv- ity analysis was performed by two methods, that were eliminating studies of single variate analysis and changing models. Fail-Safe Number （N~） were calculated to evaluate the publication bias. RESULTS： Twenty one epidemiological studies on factors relative to H pylori infection were analyzed synthetically using Meta-analysis. The pooled odds ratio （OR） values and 95%CI of the factors were as follows： history of stomach disease 2.09 （1.40, 3.12）, drinking contaminated water 2.01 （1.35, 3.00）, drinking unboiled water 3.08 （1.02,9.26）, being nursed by persons with gastric disease 2.43 （1.74, 3.40）, feeding dogs 1.75 （1.02, 3.00）, being fed with chewed food at a young age 2.66 （1.41, 5.02）, smoking 1.47 （1.09, 1.97）, eating cured food 1.94 （1.25, 3.02） and 1.87 （1.43, 2.44）, eating garlic 0.67 （0.56, 0.80）, eating bean products 0.37 （0.17, 0.79）. In the study, the relationships of factors with H pylori infection, such as sex, eating uncooked vegetables, drinking, taking antibiotics were not found out. CONCLUSION： The factors which we selected to analyze in our study influencing Chinese people infected with H pylori include stomach disease history, drinking contaminated water, drinking unboiled water, feeding dogs, being fed with chewed food, eating cured food, eating garlic and bean products.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第15期1582-1589,共8页
World Chinese Journal of Digestology
关键词
幽门螺杆菌
感染
META分析
相关因素
Helicobacter pylori
Infection
Meta-analysis
Relative factors
