摘要
目的探讨Rho激酶抑制剂对外伤性蛛网膜下腔出血(tSAH)脑血管痉挛(CVS)的治疗效果。方法58例tSAH患者随机分为常规治疗组和Rho激酶抑制剂组,采用临床症状改善情况及经颅彩色多普勒超声诊断仪(TCD)探测治疗前、治疗后(3d、5d、12d)大脑中动脉血流(MCA)速度变化来分析判断Rho激酶抑制剂对tSAH后CVS的治疗效果。结果Rho激酶抑制剂组临床症状、体征改善有效率81.16%,对照组41.69%。两组治疗前TCD检查MCA均轻度升高。Rho激酶抑制剂组治疗后(3、5、12d)MCA峰值低于常规治疗组(P<0.05)。结论Rho激酶抑制剂能明显缓解tSAH后延迟性CVS的发生,改善临床症状。TCD对外伤性蛛网膜下腔出血的早期诊断、监测CVS的发生有实用价值。Rho激酶抑制剂为临床神经外科防止tSAH后CVS提供一个新的治疗方法及依据。
Objective To investigate the curative effects of application of Rho-kinase inhibitor cerebral vasospasm following traumatic subarachnoid hemorrhage in patients. Methods 58 patients of traumatic subarachnoid hemorrhage were divided randomly into control group and Rho-kinase inhibitor therapy group. To investigate the variability of clinical feature , the probe of TCD was applied to detect the velocity of middle cerebral artery （before, 3 d, 5 d, 12 d ）. Results The clinical response rate in the Rho-I group and control group were 81.16% and 41.69% respectively. After therapy, the flow rate of cerebral vasoconstriction in middle cerebral artery were also lower in Rho-I group patients than in control group patients （P 〈 0. 05 ） Conclusion Rho-kinase inhibiting therapy can significantly alleviate cerebral vasospasm following tSAH. TCD may provide evidence for the treatment and prevention of CVS.
出处
《临床神经外科杂志》
CAS
2009年第2期74-76,共3页
Journal of Clinical Neurosurgery
