摘要
目的:探讨c-erbB-2、ki67在胃黏膜肠上皮化生(肠化)及胃癌中的表达及其与胃癌发生的关系。方法:采用免疫组织化学Envison法对27例单纯肠化(SIM)、26例不典型肠化(AIM)和37例胃癌组织分别进行c-erbB-2、ki67检测。结果:c-erbB-2、ki67在胃癌组织中的表达均高于SIM中的表达(P<0.05),AIM与胃癌组织中的表达差异无统计学意义(P>0.05)。结论:c-erbB-2、ki67在AIM及胃癌组织中高表达,AIM与胃癌发生关系密切,属于胃癌的癌前病变。
Objective： To study the expressions of c-erbB-2 and ki67 proteins in simple intestinal metaplasia （SIM）, atypical intestinal metaplasia （AIM） and gastric adenocarcinoma, and the relationships among them. Methods： The immunohistochemical EnVision method was used to determine the expressions of c-erbB-2 and ki67 in 27 cases of SIM, 26 cases of AIM and 37 cases of gastric adenocarcinoma. Results： The positive rates of c-erbB-2 and ki67 in gastric adenocarcinoma were significantly higher than that in SIM （P〈0.05）. There was no significant differences between the expression of AIM and gastric adenocarclnoma （P〉0.05）. Conclusion： The high expression of c-erbB-2 and ki67 in AiM and gastric adenocarcinoma suggested that AIM may play an mportant role in gastric adenocarcinoma, The AIM is one kind of precancerosis of gastric adenocarcinoma.
出处
《中国现代普通外科进展》
CAS
2009年第6期477-480,共4页
Chinese Journal of Current Advances in General Surgery
