摘要
目的了解1292株凝固酶阴性葡萄球菌对常用抗菌药物的耐药情况。方法回顾性分析2001-2006年医院临床分离的1292株凝固酶阴性葡萄球菌的药敏结果,采用K-B琼脂扩散法,结果判定参照2006年CLSI标准。结果凝固酶阴性葡萄球菌的分离率由2001年的11.0%下降到2006年6.4%,耐药率较高的药物有红霉素、苯唑西林和青霉素,耐药率分别为90.0%、78.9%和95.0%;而头孢吡肟、环丙沙星和左氧氟沙星的耐药率分别从2001年的17.3%、42.4%和28.7%上升到2006年的39.1%、56.0%和42.6%,四环素及复方新诺明的耐药率有明显下降趋势,分别从2001年的71.2%、72.0%下降到2006年的52.7%、33.3%,未检出万古霉素耐药菌株;120株凝固酶阴性葡萄球菌对喹奴普汀/达福普汀的耐药率为5.6%。结论6年凝固酶阴性葡萄球菌较为稳定的耐药率对今后临床用药选择及加强感染控制提供有力依据。
OBJECTIVE To study the information of drug resistance of 1292 eoagulase-negative staphylococei（CNS） isolates. METHODS There were 1292 isolates of CNS obtained from clinical patients in between 2001--2006. K-B test was used to determine the susceptibility and the results were read based on Clinical and Laboratory Standards Institute（CLSI） of the USA. RESULTS The isolating rate of CNS isolates was decreasing from 11.0% in the year of 2001 to 6. 4% in the year of 2006. During the six years, the resistant rate to erythromycin, oxacillin and benzylpenicillin was high （90. 0%, 78.9% and 95. 0%, respectively） and the resistant rate to cefepime, ciprofloxacin and levofloxaein increased from 17.3%, 42.4%, and 28. 7% in the year of 2001 to 39.1%, 56.0% and 42.6% in the year of 2006. But the resistant rate to tetracycline, trimethoprim/sulfamethoxazole decreased from 71.2% and 72.0% in the year of 2001 to 52.7% and 33.3% in the year of 2006. The resistant rate to quinupristin/dalfopristin was 5.6%. CONCLUSIONS The steady resiatence rate of CNS over the past six years provides powerful evidence for the choice of clinical medication and practice of infection control.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第11期1410-1412,共3页
Chinese Journal of Nosocomiology
基金
辽宁省科技厅博士启动基金项目(20061034)
关键词
凝固酶阴性葡萄球菌
耐药性
抗菌药物
Coagulase-negative staphylococci
Drug resistance
Antimicrobial agent
