摘要
目的探讨功能性消化不良(FD)抑郁、焦虑发生情况及对患者生活质量(QOL)及疗效的影响。方法1256例FD患者,使用综合医院焦虑、抑郁量表(HADS)进行心理自评。随机抽取30例无抑郁和(或)焦虑症状的患者,分两次按抑郁和(或)焦虑症状随机抽取30例,组成A、B、C组,三组予以医疗结算简易表(Medical Outcomes Study Short Form questions36SF-36)对QOL自评。B组予以阿米替林12.5mg,3次/d,奥美拉唑20mg,2次/d,莫沙比利5mg,3次/d,口服,A、C组予以奥美拉唑20mg,2次/d,莫沙比利5mg,3次/d,口服。疗程为8周,治疗后行HADS及SF一36评分。并记录评价治疗前后及每周躯体症状情况。结果FD患者抑郁和(或)焦虑患病率为56.37%;并抑郁和(或)焦虑症状的FD患者QOL与无抑郁、焦虑的FD患者差异有统计学意义(P<0.01):A、B组治疗后,躯体症状及QOL均改善差异有统计学意义(P<0.01或P<0.05),C组躯体症状也有显著改善(P<0.01),其QOL无明显改善(P>0.05);治疗后A、B组与C组在躯体症状和QOL上差异有统计学意义(P>0.01),A组与B组间差异无统计学意义(P<0.05);治疗后B组和C组抑郁、焦虑症状均有改善(P<0.01),但B组明显高于C组(P<0.01)。结论FD患者的抑郁和(或)焦虑症状患病率较高,其对FD患者的QOL有明显影响,抗抑郁药治疗能显著改善精神和躯体两方面症状,并能显著提高患者的QOL。
Objective To explore the occurrence of functional dyspepsia by depression symptom, anxiety symptom and its effect on the quality of life and curative effect of the patients. Methods The Hospital anxiety and depressive scale （HADS） was applied to psychological self-analysis of 1256 cases of FD.30 patients were randomly selected by sex into A groups from the FD patients who had no depression symptom and（or） anxiety symptom. 30 patients were randomly selected by sex into B groups from the FD patients who had depression symptom and（or） anxiety symptom, the same is as C groups. The SF-36 （Medical Outcomes Study Short Form questions 36 ） was applied to self-analysis the QOL of the 90 patients in three groups. In B groups, patients were given Amitriptyline 12.5 mg three times daffy and omeprazole 20mg twice daily and Mosapride 5rag three times daily. 60 patients in A and C groups who were given Omeprazole 20mg twice daily and Mosapride 5mg three times daily. The period of treatment is 8 weeks. Then , the HADS and SF-36 were applied to self-analysis of the 90 patients in threegroups after treatment. And the major clinical symptoms were evaluated before, after treatment and every week. Results The sickness rate of patients who had depressive symptom and（or） anxiety symptom in all FD patients was 56.37%. The difference（ P 〈 0.01 ）between the FD patients who had depressive symptom and（or） anxiety symptom and the FD patients who had no depressive symptom and（or） anxiety symptom in the QOL have statistical significance. Before and after treatment there was significant difference（P〈0.01 or P 〈0.05） in A groups and B groups in major clinical symptom and QOL. And there was significant difference（ P 〈 0.01） in C groups in major clinical symptom before and after treatment, but the QOL had no difference（ P 〉 0.05）. After treatment there was significant difference （ P 〈 0.01） between A groups and C groups and between B groups and C groups in major clinical symptom and QOL, but there had no difference （P〉0.05） be-tween A groups and B groups. Before and after treatment there was significant difference （P〈0.01） in B groups and C groups in de pression symptom and（or） anxiety symptom. And after treatment, those symptoms were improved in both B and C groups, but there was significant difference（P〈0.01）between B groups and C groups in depression symptom and（or） anxiety symptom. Conclusion There is high sickness rate of depression and（or） anxiety symptoms in FD patients. And the depression and（or） anxiety symptoms have significant effect on the OOL of FD patients. Antidepressant drugs are effective in relieving somatic and psychological symptoms and improving the QOL of FD patients.
出处
《临床军医杂志》
CAS
2009年第3期378-381,共4页
Clinical Journal of Medical Officers
关键词
功能性消化不良
抑郁
焦虑
生活质量
抗抑郁药
functional dyspepsia
depression
anxiety
life quality
antidepressant drug
