摘要
目的:探讨联合应用复方醋酸环丙孕酮和二甲双胍治疗多囊卵巢综合征(Polycystic ovary syndrom e,PCOS)的临床疗效。方法:30例PCOS患者于自然月经或撤退性出血第5天服用复方醋酸环丙孕酮3个周期和二甲双胍3个月,服药前后观察临床表现、盆腔超声、性激素和空腹胰岛素、空腹血糖及血脂水平的变化。结果:服药后,血清黄体生成素、睾酮和空腹胰岛素水平均显著下降(P<0.05);高密度脂蛋白胆固醇显著升高,低密度脂蛋白显著降低(P<0.05);双侧卵巢体积显著缩小,子宫内膜厚度下降(P<0.05)。结论:联合应用复方醋酸环丙孕酮和二甲双胍治疗PCOS,可减轻临床症状,降低胰岛素水平,改善异常的血激素相、血脂水平及卵巢形态。
Objective： To explore the clinical effect of compound cyproterone acetate （CCA） combined metformin on polycystic ovarian syndrome （PCOS） . Methods： 30 cases with PCOS were treated by CCA for three cycles and metformin for 3 months during the menstruation period or on the fifth day of natural withdrawal bleeding. The clinical manifestations, pelvic ultrasound, the levels of sex hormones, fasting insulin, fasting blood glucose and blood lipids were observed before and after treatment. Results ： The levels of luteinizing hormone, testosterone and fasting insulin in serum after treatment were significantly lower than those before treatment （ P 〈 0. 05 ） ; the level of high - density lipoprotein cholesterol after treatment were significantly higher than that before treatment, the level of low density lipoprotein reversed （ P 〈 0. 05 ） ; after treatment, the volumes of bilateral ovary reduced, the thickness of endometrium decreased （ P 〈 0. 05 ） . Conclusion： The treatment of （CCA） combined metformin can alleviate clinical symptoms, decrease the insulin level, improve the abnormal serum hormones, blood lipids levels and ovarian morphology in patients with PCOS.
出处
《中国妇幼保健》
CAS
北大核心
2009年第18期2569-2570,共2页
Maternal and Child Health Care of China
关键词
多囊卵巢综合征
醋酸环丙孕酮
二甲双胍
Polycystic ovarian syndrome
Compound cyproterone acetate
Metformin
