摘要
目的探讨苯妥英钠（PHT）对癫痫儿认知功能的影响及叶酸制剂对其认知功能障碍的改善作用。方法14名患儿采用自身前后对照，于PHT治疗3mo后加服叶酸制剂，分析PHT治疗前、治疗3mo、治疗6mo后认知功能及血清叶酸、维生素B12的变化。结果PNT治疗3mo后，患儿的记忆力、注意力、精细运动及视觉保持能力明显降低。接受叶酸制剂后患儿认知功能明显改善。血清叶酸、维生素B12与认知功能之间有显著相关性。结论PHT对癫痫患儿认知功能的影响与PHT引起患儿血清维生素B12水平降低有关。加服叶酸制剂对癫痫患儿的认知功能有显著的改善作用。
Objectives To investigate the improvement effect of folic acid on phenytoin-induced cognitive dysfunction in epileptic children. Methods A battery of psychological tests and self-control design were used in 14 epileptic children, to evaluate the cognitive functions at the beginning and after treated 3 and 6 months with phenytoin respectively. Serum levels of folio acid and vitamin B12 were examined at the same time. Folio acid was added to them at the treated 3 months. Serum concentrations of PHT were measured by HPLC after PHT treated 3 and 6 months respectively. Results Cognitive function of the epileptic children was obviously influenced and serum levels of folic acid and vitamin B12 were severely reduced after treated by PHT. Received folic acid 3 months, cognitive functions were obviously improved in the children. Conclusions Phenytoin-induced cognitive dysfunction correlated with levels of serum folic acid and vitamin B12 reduced by PHT and maybe improved by supplemental folic acid method.
出处
《实用儿科临床杂志》
CAS
CSCD
1998年第2期100-102,共3页
Journal of Applied Clinical Pediatrics
