摘要
目的探索与绝经后妇女冠心病发病有关的体内性激素（ＳＨ）的变化规律。方法连续测定５２例绝经１年以上的女性冠心病患者（Ⅰ组，平均年龄６３．８±０．８３岁）、３８例绝经１年以上无冠心病的妇女（Ⅱ组，平均年龄６４．６±０．７９岁）及８６例无冠心病的正常育龄行经妇女（Ⅲ组，平均年龄４１．５±０．６８岁）的血清雌二醇（Ｅ２）、孕酮（Ｐ）、促卵泡刺激素（ＦＳＨ）、促黄体生成素（ＬＨ）及血脂谱。结果Ⅰ组Ｅ２水平明显降低，分别为Ⅱ、Ⅲ组Ｅ２水平的５３％及２８％；Ｐ水平也有下降趋势，但三组之间差异无显著性；Ⅰ组ＦＳＨ、ＬＨ水平较Ⅱ、Ⅲ组显著增高。Ⅰ、Ⅱ组与Ⅲ组相比，总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬＣ）水平均显著增高；而高密度脂蛋白胆固醇（ＨＤＬＣ）水平显著降低；Ⅰ组较Ⅱ组ＴＣ、ＬＤＬＣ水平更显著增高；ＨＤＬＣ水平更显著降低（Ｐ均＜０．００１）。线性相关分析发现，Ｅ２与ＦＳＨ、ＬＨ、ＴＣ、ＴＧ、ＬＤＬＣ水平呈显著负相关，与ＨＤＬＣ水平呈显著正相关，总体相关系数分别为－０．６８、－０．５６、－０．６３、－０．３７、－０．５３、０．２２（Ｐ值均＜０．００１）。结论绝经后妇女冠心病患者存在着严?
Objective To investigate the endogenous sex hormone disorder and adverse change of serum lipid profiles in postmenopausal women with coronary heart disease (CHD). Methods Fifty two postmenopausal women with CHD (group Ⅰ, 63.8±0.83 years), 38 postmenopausal women without CHD (group Ⅱ, 64.6± 0.79 years) and 86 premenopausal women without CHD as control (group Ⅲ, 41.5±0.68 years) were selected to compare the serum levels of estradiol (E 2), progesterone (P), follicle stimulating hormone (FSH), luteinizing hormone (LH), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL C) and low density lipoprotein cholesterol (LDL C). Results Analysis of variance demonstrated that menopause was associated with significantly higher serum levels of FSH,LH, TC, TG, LDL C, and lower serum levels of E 2, HDL C. The changes of all the above indices were more pronounced in group Ⅰ than those in group Ⅱ. E 2 level showed a 72% decrease in group Ⅰ compared with group Ⅲ. Correlation analysis showed that serum E 2 level was negatively correlated to serum levels of TC ( r =-0.63, P <0.01 ), TG ( r =-0.37, P <0.01 ) and LDL C ( r = -0.53 , P <0.01), but positively associated with HDL C ( r =0.22, P <0.01).Conclusion The study indicates that significantly lower level of serum E 2, which could induce adverse serum lipid profile, is one of the main risk factors of CHD in postmenopausal women.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1998年第3期181-183,共3页
Chinese Journal of Cardiology
关键词
冠心病
绝经后
性激素
menopause coronary heart disease estrogen lipid
