期刊文献+

microRNA与肿瘤转移

MicroRNAs and neoplasm metastasis
原文传递
导出
摘要 微RNA(microRNA)又称微小RNA、miRNA,是在转录后水平对编码蛋白质的mRNA进行调控的一族内源性非编码小RNA。越来越多的研究结果证实microRNA在肿瘤转移过程中发挥重要作用,肿瘤转移相关microRNA的研究已成为关注的热点。microRNA可能给肿瘤转移的诊断与治疗带来新的突破。 MicroRNA,known as micro-RNA or miRNA, is a cluster of endogenous non-coding small RNAs regulating protein-coding mRNAs at the post-transcriptional level. More and more studies confirm the important role of microRNA in tumor metastasis, and the research of tumor metastasis-related microRNA has become the focus of attention. MicroRNAs may bring breakthroughs on diagnosis and treatment of tumor metastasis.
出处 《国际肿瘤学杂志》 CAS 2009年第5期361-363,共3页 Journal of International Oncology
关键词 MICRORNA 肿瘤转移 微RNA 内源性非编码 MicroRNAs Neoplasm metastasis
  • 相关文献

参考文献1

二级参考文献51

  • 1Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005; 11:1753-1761.
  • 2Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524.
  • 3Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
  • 4Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr Opin Drug Discov Dev 2005, 8:557-566.
  • 5Brennecke J, Stark A, Russell R.B, Cohen SM. Principles of microRNA-target recognition. PLoS Biol.2005; 3:e85.
  • 6Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122:6-7.
  • 7Chen CZ, Li L, Lodish HF, Bartel DE MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83- 86.
  • 8Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006; 94:776-780.
  • 9Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006; 16:4-9.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.

共引文献210

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部