摘要
给大鼠连续腹腔注射醋酸铅，可使小鼠红细胞和脑组织中的脂质过氧化物含量明显升高，且降低全血谷胱甘肽过氧化物酶活性；同时注射锗和铅可使脂质过氧化物含量显著下降，而血中谷胱甘肽过氧化物酶的活性明显提高．
The effect of germanium on mouse lipid perxidation induced by lead was studied by administering i. p. carboxyethylgermanium sesquioxide (Ge132, 25mg/kg) or/and lead acetate (PbAc, 15mg/kg) for 20 days. The results showed that the lipid peroxidation in mouse red blood cells and brain caused by the injection of lead acetate was significantly antagonized by Ge132 .The decrease of activity of glutathione peroxidase in mouse whole blood caused by lead acetate was also antagonized by the injection of Ge132,indicating that Ge132 has antioxidation.
出处
《延边大学医学学报》
CAS
1998年第1期5-7,共3页
Journal of Medical Science Yanbian University
关键词
铅中毒
过氧化脂质类
锗
小鼠
lead poisoning
lipid peroxides
germanium
