摘要
目的初步探讨同型半胱氨酸(Hcy)代谢相关酶胱硫醚β-合酶(CBS)基因C572T基因突变频率在广西河池地区妊娠期高血压疾病(HDP)发病中的作用。方法采用等位基因特异性扩增(ASA)技术检测63例HDP患者(观察组)和32例孕期经过顺利的正常孕妇(对照组)CBS基因C572T基因型。结果HDP组CBS基因C572T T/T、C/T和C/C基因型频率分别为4.76%、84.13%和11.11%;对照组分别为3.13%、87.50%和9.37%;HDP组C等位基因频率为53.17%、T等位基因频率为46.83%,对照组分别为53.13%和46.87%,二者比较,差异无统计学意义(P>0.05)。结论CBS C572T基因突变频率与HDP发病无明显相关性,其基因突变频率可能不足以构成广西河池地区HDP发病的独立遗传危险因素。
Objective To study the effect of mutation frequency of cystathionine β-synthase（CBS） in patients with hypertensive disorder complication pregnaney（HDP）. Methods 63 patients with HDP and 32 healthy pregnant women were divided into HDP group and control group, their C572T genotypes were detected by the technique of Allele-specific amplification （ASA）. Results The frequency of CBS gene type T/T,C/T and C/C were 4.76% ,84.13% and 11.11% respectively in HDP group, while the control group were 3.13 %, 87.50 %, 9.37 % respectively. The frequency of C alleles and T alleles were 53.17% and 46.83% in HDP group,while the control group were 53.13% and 46.87%. there was no significant difference between the two groups（ P 〉0.05）. Conclusion There was not significant correlation between C572T and hypertensive disorder complication pregnancy,its mutation frequency may not be independent risk factor for hypertensive disorder complication in He Chi population.
出处
《右江医学》
2009年第2期132-134,共3页
Chinese Youjiang Medical Journal
关键词
妊娠期高血压疾病
胱硫醚Β-合酶
同型半胱氨酸
基因频率
Hypertensive disorder complication pregnancy
Cystathionine β-synthase
Homocysteine
gene frequency
