摘要
目的检测小青龙汤对慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者诱导痰细胞I、L-8和MMP-9的影响,以探讨小青龙汤对COPD患者气道炎症及气道重塑的影响。方法将80例稳定期COPD患者随机分入治疗组和COPD对照组。另有40例非吸烟健康者作为健康对照组。所有COPD患者均接受沙美特罗替卡松粉(50μg/100μg)吸入。治疗组另给予小青龙汤口服。治疗前后分别检测诱导痰细胞、白细胞介素8(IL-8)和基质金属蛋白酶9(MMP-9)水平。结果治疗后,治疗组和COPD对照组诱导痰细胞总数、中性粒细胞比例和MMP-9水平均有所下降。治疗组下降的程度优于COPD对照组。治疗前后诱导痰IL-8水平相近。结论小青龙汤可以有效降低诱导痰细胞总数、中性粒细胞比例和MMP-9水平。COPD患者接受小青龙汤治疗可以改善气道炎症,并有望减轻气道重塑。
Objective To study the effects of Xiaoqinglongtang decoction on the cell counts and the levels of IL-8 and MMP-9 in induced sputum in patients with chronic obstructive pulmonary disease （COPD）. Methods A total of 80 patients with stable COPD were enrolled and randomly divided into 2 groups, including test group and COPD control group. 40 nonsmoke healthy individuals were enrolled in control group. All patients with COPD were treated with salme- terol/fluticasone （50μg/100μg）. The test group was treated with Xiaoqiongtang decoction. The cell counts and the levels of IL-8 and MMP-9 were measured. Results The total cell counts and the percentage of neutrophils ceil counts and sputum supernatant concentration of MMP-9 of COPD in test group were lower than that of the COPD control group after treatment. The sputum supernatant concentration of IL-8 of COPD decveased slightly in all groups. Conclusions Xiao- qiongtang decoction can decrease the total celt counts and the percentage of neutrophils cell counts and increase expression of MMP-9. Xiaoqiongtang decoction can reduce airway inflammation and reverse airway remodeling.
出处
《西部医学》
2009年第4期575-577,共3页
Medical Journal of West China
关键词
慢性阻塞性肺疾病
基质金属蛋白酶9
小青龙汤
气道重塑
Pulmonary disease
Chronic obstructive
Matrix metalloproteinases-9
Xiaoqiongtang decoction
Airway remodeling
