摘要
目的探讨舍曲林对2型糖尿病患者合并抑郁症的疗效。方法将60例合并抑郁症的2型糖尿病患者,随机分为研究组(服用舍曲林组,30例)和对照组(未服用舍曲林组,30例),治疗8周。以汉密尔顿抑郁量表(HAMD)评定疗效,用糖化血红蛋白(HbA1c)水平监测血糖控制情况。结果治疗8周后,研究组抑郁症状的改善明显优于对照组(P<0.01),痊愈率(43.3%)和有效率(66.7%)均明显高于对照组(分别为16.7%和36.7%)(P<0.01);研究组HbA1c水平较治疗前显著下降,且明显低于对照组(P<0.01)。结论舍曲林能明显改善2型糖尿病患者的抑郁症状,更有利于患者血糖的控制。
Objective To investigate the efficacy of sertraline for treating type 2 diabetes mellitus（DM）patients accompanied by depression. Methods A total of 60 type 2 DM patients with depression were divided into control group and treatment group. Control group was given conventional drugs,and treatment group was given both conventional drug and sertraline for the treatment of 8 weeks. HAMD was used to assess efficacy. Results The healing rates and the response rates in treatment group and control group were 43.3% and 66.7%, 16. 7% and 36.7% ,respectiely,there had significant differences between two groups. Level of HbAlc in treatment group significantly decreased after 8-week treatment compared to control group. Conclusion Sertraline is effective not only for controlling depressive symptoms ,but also for improving the controlling of blood glucose in patients with type 2 diabetes mellitus.
出处
《精神医学杂志》
2009年第2期112-113,共2页
Journal of Psychiatry
关键词
舍曲林
糖尿病
抑郁症
Sertraline Diabetes mellitus Depression
