摘要
目的比较Sokal和Hasford积分系统在研究慢性粒细胞白血病(CML)中的临床意义。方法204例患者按治疗方案与两种积分系统分别进行分组,比较干扰素两种积分系统对慢性期CML患者生存期的影响,并在不同危险度组内观察干扰素对患者生存期的影响。结果干扰素、Sokal和Hasford积分系统对CML患者的预后均有显著影响(P均<0.001),但多变量分析发现仅有Hasford积分是影响预后的独立因素。在Hasford中高危组与Sokal高危组内,干扰素并不能明显延长患者的生存时间。结论Sokal和Hasford积分系统能较好地预测CML患者的预后,对确定高危组患者后者更为准确。按预后评分系统将患者分组,有利于治疗方案的合理选择。
Objective To compare clinic significance of Sokal and Hasford prognostic scoring sys- tems in research of chronic myeloid leukemia(CML).Methods 204 patients with CML were grouped on the basis of either different therapy protocols or two scoring systems,and the prognostic strength of interferon-αand risk profile were compared.The impact of intefferon-αwas also evaluated with the relative risk,either ac- cording to Sokal or Hasford scoring systems.Results Interferon-α,Sokal and Hasford scoring systems were all strong predictors of survival (P<0.001),but multivariate analysis by Cox regression showed that only Has- ford score was independent prognostic factor.Intefferon-αwas incapable of prolonging survival in patients in Sokal high-risk group and Hasford high-intermediate-risk group markedly.Conclusion Sokal and Hasford scoring systems were important prognostic factors for patients with CML,and the latter is considerably more precise in identifying high-risk patients.Patients should be categorized according to the risk profile for choos- ing appropriate treatment protocol.
出处
《白血病．淋巴瘤》
CAS
2007年第2期93-96,共4页
Journal of Leukemia & Lymphoma
