摘要
采用放射免疫测定法检测尿白蛋白，筛选出早期糖尿病肾病４２例，随机分为两组，通过自身对照试验比较应用依那普利治疗及常规治疗对早期糖尿病肾病的影响，结果显示，依那普利治疗４周后，患者有效肾血浆流量上升，肾小球滤过分数、肌酐清除率下降，尿白蛋白减少，糖基化血红蛋白，过氧化脂质的水平降低。揭示依那普利具有减少尿蛋白排泄，抗蛋白质非酶糖基化及脂质过氧化，改善肾功能的作用。
To assess the effects of enelapril and routine method on kidney function in early diabetic nephropathy (END) screened by radio-immune method , 42 patients with END were selected and divided randomly into either enalapril group (n=21) or routine method group (n=21) After treatment for 4 weeks ,significant rise in renal plasma flow and reduction in filtration fraction, glomerular filtration rate of creatinine, urinary albumin excretion rate, Glucosylated hemoglobin and lipid peroxide were observed in enalapril group The results suggested that enalapril can reduce the albuminuna of patients with END and have anti-non-enzymatic glycosylation and anti-lipid peroxide effect Enalapril has a beneficial effect on kidney function in END [WT5”HZ〗
出处
《广西医学》
CAS
1998年第1期15-17,共3页
Guangxi Medical Journal
