摘要
目的探讨抗结核药物对肺结核合并乙肝患者肝功能的影响。方法对肺结核合并乙肝患者(观察组)采用标准化抗结核药物治疗方案,对治疗过程中肝功能的变化进行分析,并对同期采用同样治疗方案治疗肺结核乙肝病毒阴性患者(对照组)治疗过程中肝功能的变化进行分析比较。结果观察组肝损害率(55.2%),明显高于对照组(15.7%),差异有显著性(P<0.01)。出现时间、恢复时间差异亦有显著性(P<0.05,P<0.01)。结论抗结核药物对肺结核合并乙肝患者肝功能的影响为肝功能损害发生率高、出现早、恢复慢。
[Objective] To study the effect of antituberculosis drugs on liver functions of patients suffered with pulmonary tuberculosis and type B hepatitis. [Methods] Patients suffered with pulmonary tuberculosis and type B hepatitis （experimental group） were treated with standard antituberculosis drug therapeutic regimen and the changes of liver functions appearing during the treatment were analyzed, while same therapeutic regimen and liver function analysis were performed on patients suffered with only pulmonary tuberculosis （control group）. [Results] The proportion of hepatic lesion in experimental group （50%） is much higher than that of the control group （8.5%） （P 〈0.01）. The emergence time and recovery time also show significant difference between these two groups （P 〈0.05, P 〈0.01）. [Conclusion] The hepatic lesion caused by antitubereulosis drugs to patients suffered with pulmonary tuberculosis and type B hepatitis shows high incidence rate, early emergence and slow recovery.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第3期462-464,共3页
China Journal of Modern Medicine
关键词
肺结核
乙肝
抗结核药物
pulmonary tuberculosis
type B hepatitis
antituberculosis drug
