摘要
目的了解淋球菌流行株对抗菌药物的敏感性,为淋病的防治提供实验依据。方法改良碘量法检测β-内酰胺酶,纸片扩散法检测98株淋球菌对9种抗菌药物的敏感性。结果质粒介导的产青霉素酶淋球菌(PPIVG)和质粒介导的高度耐四环素淋球菌(TRNa)分别为55株(56.12%)和20株(23.47%),在测定的9种抗菌药物中,淋球菌耐药性较高的依次为四环素、头孢美唑、青霉素、环丙沙星、氧氟沙星。耐药率分别为36.73%、50%、56.12%、74.45%、80.61%,而敏感性较高的4种抗菌药物依次为头孢呋辛、头孢三嗪、头孢呲肟、壮观霉素,敏感率分别为72.44%、79.60%、77.55%、91.84%。结论青霉素、四环素以及氟喹诺酮类药物已不宜作为常德地区治疗淋病的常规药物,壮观霉素可作为治疗淋病的首选药物,但已出现耐药菌株,应当引起高度警惕。
Objective To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changde, and to provide a reference for the prevention and treatment of gonorrhea. Methods β2Lactamase was determined by a modified iodometric method and the susceptibility to 9 antibiotic agents was tested by the disc diffusion method in 98 isolates. Results Plasmid mediated penicillinase producing Neisseria gonorrhoeae and plasmid mediated tetracycline resistant Neisseria gonorrhoeae were 56.12% and 23.47%, respectively. Of all the 9 antibiotic agents, tetracycline, cefmetazole, penicillin, ciprofloxacin, and ofloxacin had a higher resistance and the percentages of resistance were 36.73%, 50.00%, 56.12 %, ？4.45%, and 80.61%, respectively. On the other hand, cefuroxime, ceftriaxone, cefepime, and spectinomycin had a higher susceptibility and the percentages of susceptibility were 72.44 %, 79.60 %, 77.55 %, and 91.84 %, respectively. Conclusions Penicillin, tetracycline and fluoroquinolone can not be used as routine agents to cure gonorrhea; and spectinomyein can be used as a primary medicine to cure gonorrhea in Changde, but clinical doctors need to pay more attention to it because resistant strains have come into existence.
出处
《实用预防医学》
CAS
2009年第1期251-253,共3页
Practical Preventive Medicine
关键词
淋球菌
纸片扩散法
药物敏感性
常德
Neisseria gonorrhoeae
Disk diffusion
Antimicrobial susceptibility
Changde
