摘要
目的：肺癌的发病率及死亡率全球最高，老年肺癌的发病人数亦在增加。本文旨在评价老年原发性支气管肺癌的生存情况及探讨影响老年肺癌生存和预后的因素。方法：回顾性总结新疆医科大学第一附属医院2002年1月至2007年1月间收治的450例年龄≥70岁的老年肺癌患者的病例资料，评价其1、3年生存率并进行影响生存和预后的单因素及多因素分析。结果：老年肺癌患者总的1、3年生存率分别为52．12％、15．57％，接受治疗的患者1、3年生存率均明显高于未经治疗者（P〈0．05，分别为52．8％：10．18％；17．26％：0），其中不同治疗模式中，手术组1、3年生存率均高于化疗组及支持对症组（P〈0．05），其余各组未发现有差异。单因素分析中民族、付费方式、治疗前的一般状况评分（PS）、体重减轻，有无转移、病理类型、分期和治疗模式与预后有统计学意义（P〈0．05）。而性别、吸烟指数、有无合并症、血红蛋白水平、白蛋白水平等均未发现与长期生存率相关；多因素分析显示治疗前的一般状况（PS）评分、分期、体重减轻是影响老年肺癌预后的独立因素。结论：老年肺癌患者接受治疗能够提高其1、3年生存率。对于早期患者手术治疗仍为最有效的治疗方法之一。治疗前的一般状况（PS）评分、临床分期、体重减轻是影响老年肺癌预后的独立因素。
Objective： To evaluate the survival status and prognosis factors of primary bronchogenic carcinoma in the elderly. Methods： A total of 450 cases of lung cancer in the elderly seen in our hospital between January 2002 and January 2007 were retrospectively reviewed. Patient survival and prognostic factors were analyzed. Results： The 1- and 3-year overall survival rates were 52.12% and 57%, respectively. The 1- and 3-year survival rates were higher in treated patients than in untreated patients （52.8%：10.18%; 17.26%：0, P〈 0.05）. Multivariate analysis showed that patients＇ nation, payment methods, pre-treatment performance status （PS） score, weight loss, metastasis, pathology, staging and treatment were related to long-term survival rate. The 1- and 3-year survival rates in patients treated with surgery was higher than in those who received chemotherapy and supportive care （P〈0.05）. Single factor analysis revealed that gender, smoking index, complications, hemoglobin level, and albumin level were not correlated with survival rate. Multi-factor analysis showed that pre-treatment PS score, stage and weight loss were independent prognostic factors for lung cancer in the elderly. Conclusion： Treatment can improve the survival of lung cancer in the elderly. For those with early stage lung cancer, surgery can achieve better results than chemotherapy and supportive care. Pre-treatment PS score, stage, and weight loss are independent prognostic factors.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2009年第2期70-74,共5页
Chinese Journal of Clinical Oncology
关键词
老年原发性支气管肺癌
生存评价
预后因素
Primary bronchogenic carcinoma in the elderly
Survival evaluation
Prognostic factor
