摘要
目的观察中药舒肝凉血方对服用三苯氧胺的乳腺癌患者潮热的改善情况。方法选择2004年10月—2006年11月乳腺癌诊断明确,服用三苯氧胺(他莫西芬tamoxifen,TAM)出现潮热症状的患者73例,随机分为治疗组(37例)和对照组(36例),治疗组予中药舒肝凉血方,对照组予安慰剂。观察潮热及睡眠改善情况。以治疗前1周每日平均潮热次数及睡眠情况作为基线。采用国际认可的Kupperman评分方法,比较治疗前后潮热及睡眠改善情况。结果可评价病例66例,治疗组33例,对照组33例。潮热症状减轻情况:治疗组潮热症状消失5例(15.2%),减轻14例(42.4%),无变化14例(42.4%);对照组无患者症状消失,减轻10例(30.3%),无变化23例(69.7%)。两组比较,差异有统计学意义(P=0.012)。睡眠改善情况:治疗组睡眠改善21例(63.6%),无变化12例(36.4%);对照组睡眠改善13例(39.4%),无变化20例(60.6%)。两组比较,差异有统计学意义(P=0.002)。结论中药舒肝凉血方可减轻服用三苯氧胺乳腺癌患者的潮热症状并改善睡眠情况。
Objective To observe the effect of Shugan Liangxue Compound （SLC） for relieving hot flashes in breast cancer patients medicated with tamoxifen. Methods A randomized, double blind clinical trial for observing the therapeutic effects of SLC was carried out on 73 breast cancer patients hospitalized from October 2004 to November 2006, who were treated with tamoxifen, and revealed hot flashes. They were radomly as- signed to two groups, the 37 in the treated group treated by SLC, and the 36 in the control group treated with pla- cebo. Taking the improvement of hot flashes as an end point index and that of sleep as a secondary index, the effects of treatment were compared by Kupperman scoring with the average times of hot flashes per day and condition of sleep within 1 week before treatment as baseline. Results The effects on 66 patients （33 in the treated group and 33 in the control group） were evaluable. In the treated group hot flashes disappeared in 5 patients （15.2%）, relieved in 14 （42.4%） and unchanged in 14 （42.4%） ; while in the control group, it disappeared in none, relieved in 10 （30.3%） and unchanged in 23 （69.7%）, comparison between groups showed significant difference （P=0.012）. As for the condition of sleep, it was improved in 21 （63.6%） and unchanged in 12 （36.4%） in the treated group; while the condition of sleep in the control group was improved in 13 （39.4%） and unchanged in 20 （60.6%）, also with significant difference between the two groups （P = 0. 002 ）. Conclusion SLC is effective in alleviating tamoxifen-induced hot flashes and improving the condition of sleep.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2009年第1期30-33,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
北京市首都医学发展科研基金资助项目(No.03-Ⅱ-07)
关键词
舒肝凉血方
乳腺癌
潮热
睡眠状况
Shugan Liangxue Compound
breast cancer
hot flashes
condition of sleep
