摘要
目的观察Rho激酶抑制剂盐酸法舒地尔治疗急性脑梗死的临床疗效和安全性。选择我院2007年7月～2008年4月治疗的急性脑梗死患者60例，随机分为治疗组30例，对照组30例，对照组给予常规治疗，治疗组给予盐酸法舒地尔，观察评价2组患者的神经功能缺损程度的恢复情况及日常生活能力评分等。结果治疗组与对照组神经功能缺损程度的恢复及日常生活能力比较差异有显著性（P〈0．05）。结论急性脑梗死发病后48h内用法舒地尔，可有效改善患者神经功能缺损和日常生活能力，且无严重不良反应。
Objective To investigate the clinical efficacy and safety of fasudil, a Rho-kinase inhibitor, in the treatment of acute ischemic stroke. Methods A randomized study was designed to evaluate effect of fasudil on acute cerebral infarction, with routine therapy as placebo - control. Sixty patients were chosen from July 2007 to April 2008 and were divided into 2 groups： fasudil group （30 patients） and control group （30 cases）. Excellency, efficacy, improvement of neurological function, and activities of daily living were observed. Results In the fasudil group, excellency, efficacy, improvement of neurological function, and activities of daily living were elevated markedly compared with those in the placebo - control group （P〈0.05）. Conclusion Fasudil can increase the neurological function and activities of daily living in the therapy of acute cerebral infarction. Fasudil is a safe medicine.
出处
《中南药学》
CAS
2009年第1期63-65,共3页
Central South Pharmacy
关键词
脑梗死
法舒地尔
RHO激酶
神经功能
日常生活能力
brain infarction
fasudil
Rho-kinase
neurological function
activities of daily living
