摘要
目的:探讨visfatin与老年2型糖尿病及其大血管并发症和相关代谢指标的关系。方法:将66例老年糖尿病患者分为合并大血管病变组(MCV)35例和非大血管病变组(nMCV)31例,并选64例健康人做对照。采取酶联免疫测定法(ELISA)测定空腹血清visfatin浓度;并测定各组的空腹血糖、胰岛素、血压和血脂水平;用胰岛素抵抗指数(HO-MA-IR)HOMA-IR评价胰岛素抵抗,分析各指标间的相关性及与大血管并发症的相关性。结果:①老年2型糖尿病组血清visfatin浓度高于正常对照组,差异有统计学意义(P<0.01)。但正常对照组与2型糖尿病组中nMCV组比较,visfatin浓度差异无统计学意义(P>0.05)。②老年2型糖尿病组中大血管病变组(MCV)血清visfatin浓度明显高于非大血管病变组(nMCV),差异有统计学意义(P<0.01)。③相关分析显示,老年2型糖尿病组血清visfatin浓度与腰围(WC)、甘油三酯(TG)均呈显著正相关,与性别、年龄、HOMA-IR呈正相关。进一步以visfatin为应变量,以年龄、性别、BMI、WC、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、HOMA-IR为自变量进行多元逐步回归分析,TG、WC和年龄是血清visfatin独立相关因素。④在老年T2DM组,以有无大血管并发症为应变量(Y=1,n=0),各指标为自变量,进行logistic回归分析,visfatin进入回归方程。结论:血清visfatin与2型糖尿病的发病不相关,但在老年2型糖尿病中与其大血管并发症有关。
Objective：To investigate the relationship between serum visfatin and eldly type 2 diabetes mellitus,its ma- crovascular complication and relative indexes. Methods：Sixty-six eldly type 2 diabetes mellitus subjects were divided into macrovascular complication group（MCV group） and noncomplication group （nMCV group ）, and 64 healthy subjects were controls. ELISA technique was employed to determine the serum visfatin;at the same time, the fasting blood glu- cose,insulin and blood lipid were detected;insulin resistance was evaluated by the HOMA-IR. Results： （1）The concentra tion of serum visfatin was increased in type 2 diabetes mellitus group compared with that in control group（P-（0.01）. But the difference of the concentration of serum visfatin between control group and nMCV group was not significant（P〉 0.05）. （2）The concentration of serum visfatin was increased in group MCV compared with that in nMCV group, the difference was significant （P〈0.01）. （3）In MCV and nMCV groups, according to correlation analysis, the concentration of serum visfatin was correlated positively with the age, sex, WC, TG, and HOMA-IR. Multiple step wise regression a- nalysis revealed that the independent variable that was associated with serum visfatin levels was TG, WC and age. （4）In MCV and nMCV groups,logistic regression analysis was done, by regarding macrovascular complication as independentle Y （Y=1, n = 0）, and other indexes dependent as variables, visfatin entered regression equation. Conclusion：Serum visfatin is not related to type 2 diabetes mellitus, but closely related to macrovascular complication in eldly type 2 diabetes mellitus.
出处
《华西医学》
CAS
2009年第1期115-118,共4页
West China Medical Journal
