摘要
【目的】了解南京市儿童血清25-羟维生素D[25-hydroxyvitaminD，25-（0H）D]、甲状旁腺激素（parathy-roid hormone，PTH）和骨特异性碱性磷酸酶（bone—specificalk aline phosphatase，BAP）的水平，为临床应用维生素D制剂提供参考。【方法】以儿童保健健康检查门诊、幼儿园及住院共142名0～10岁儿童为研究对象（76名健康儿童，61名上感儿童，5名肺炎儿童），取清晨空腹静脉血，用酶联免疫法检测血清25-（OH）D、PTH和BAP的水平。【结果】南京市健康儿童血清25-（OH）D平均水平为（80．5±29．3）nmol／L，PTH为（1．8±0．9）pmol／L，BAP为（71．0±30．3）ug／L；如以25-（0H）D〈50nmol／L作为维生素D缺乏的标准，则其发生率为10．5％；上述指标随年龄增长呈有规律的波动趋势；患病儿童血清25-（0H）D平均水平为（65．6±32．3）nmol／L，低于正常儿童（P〈0．05）。【结论】南京市健康儿童的维生素D营养状况较好；血清25-（OH）D水平随年龄波动；疾病状态下维生素D水平明显降低。
[ Objective] To get the data of serum 25-hydroxyvitamin D [ 25 （OH） D], parathyroid hormone（PTH）, bonespecific alkaline phosphatase（BAP） levels of 0410 y old children in Nanjing city, and to get some potentially useful data for the clinical practice of vitamin D supplements. [Methods] 142 subjects（66 were sick） aged 0-10 y were recruited during 2007/12 -2008/03. Draw venous blood from these subjects after an overnight fast in the morning, and quantitatively determine the serum 25-（OH）D,PTH and BAP levels of the blood samples with ELISA method. [Results] The average level of serum 25-（OH）D was （81.3±29.3） nmol/L in all healthy children, vitamin D deficiency[25-（OH）D〈50 nmolA.] was observed in 10. 5% of these children. The levels of serum 25-（OH）D,PTH,BAP fluctuate with increasing of age regularly. The level of serum 25-（OH）D was （65.6±32.3）nmol/L in sick children,significantly lower than that of healthy children（P〈0.05）. [Conclusions] The vitamin D status of Nanjing children is quite well. With increasing of age,the level of serum 25-（OH）D significantly fluctuates, ascending first and descending later; On the contrary, the levels of serum PTH and BAP descend first and ascend later; Sick children have significantly lower level of serum 25-（OH）D than healthy children.
出处
《中国儿童保健杂志》
CAS
2009年第1期15-16,20,共3页
Chinese Journal of Child Health Care
基金
江苏省卫生厅科技项目(H200321)
