摘要
目的:研究拟人类血管性痴呆(vascular dementia,VD)模型大鼠学习记忆功能的改变.方法:(1)采用改良的大脑中动脉栓塞(middle cerebral artery occlusion,MCAO)法,建立VD样学习记忆障碍的大鼠模型.实验动物随机分成3组:VD模型组、假造模实验对照组和正常对照组.(2)采用水迷宫行为学试验,观测各组大鼠的空间学习记忆功能.结果:VD模型大鼠发生了空间学习记忆功能障碍,与两对照组比较有显著性差异(P<0.01).结论:(1)本研究制成的VD样学习记忆障碍的动物模型具有较好的仿真脑性痴呆的特点.(2)水迷宫试验能较真实地反映动物学习记忆功能.
Objective： To research on learning and memory impairment of vascular dementia （VD） rat model. Methods： （1） by improved middle cerebral artery occlusion （MCAO） method, VD-like rat model on learning and memory impairment has been made. The experimental animals were devided randomly into three groups： VD model group, false model group and normal control group. （2） Learning and memory function of various group rats were assessed by the water maze test. Results： Learning and memory function of VD model rats has impaired significantly compared with that in two other groups （P 〈 0.01）. Conclusion： （1） VD-like animal models on learning and memory impairment have good characters of dementia. （2） The water maze test can assess accurately the learning and memory function of rats.
出处
《江汉大学学报（自然科学版）》
2008年第4期54-56,共3页
Journal of Jianghan University：Natural Science Edition
基金
湖北省卫生厅科研计划项目(2005-JX2C35)
关键词
血管性痴呆
动物模型
大脑中动脉栓塞
水迷宫试验
学习记忆
vascular dementia （VD）
animal model
middle cerebral artery occlusion （MCAO）
water maze test
learning and memory
