期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

2型糖尿病伴非酒精性脂肪肝患者胰岛功能及血脂分析 被引量：8

在线阅读 下载PDF
导出
摘要 目的:探讨新诊断2型糖尿病(T2DM)患者中非酒精性脂肪肝(NAFL)与血脂、胰岛素抵抗及胰岛功能的关系。方法:所有患者行OGTT试验,比较54例T2DM伴NAFL患者和48例T2DM不伴NAFL患者的体质指数(BMI)、血脂、血糖、胰岛素抵抗及胰岛功能,并进行多元回归分析。结果:T2DM伴NAFL组BMI、TC、TG、LDL-C、F-INS、P-INS、HOMA-IR显著高于不伴NAFL组(P<0.05);△I30/△G30低于不伴NAFL组(P<0.05),TG及HOMA-IR均为NAFL的独立危险因素。结论:新诊断T2DM伴NAFL患者,具有血脂紊乱、胰岛素抵抗及胰岛功能早期相分泌受损更严重的特点。
作者 徐小华 吴锦丹 谢晓竞 马建华
机构地区 南京医科大学附属南京第一医院内分泌科
出处 《实用医学杂志》 CAS 2008年第22期3890-3891,共2页 The Journal of Practical Medicine
关键词 脂肪肝 酒精性 胰岛素抵抗 早期相分泌
分类号 R587.1 [医药卫生—内分泌] R575.5 [医药卫生—消化系统]
  • 相关文献

参考文献8

  • 1Mc Cullough A J. Update on nonalcoholic fatty liver disease [J]. J Clin Gastroentenrol, 2002, 34 (3) : 255.
  • 2Chouhury J, Sanyal A J. Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease [ J ]. Clin Liver Dis, 2004, 8 ( 3 ) : 575-594.
  • 3姚定国,项柏康,杨建锋,陈芝芸.2型糖尿病合并非酒精性脂肪肝患者血清瘦素与胰岛素抵抗的关系[J].中国糖尿病杂志,2006,14(5):331-332. 被引量：4
  • 4中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊断标准[J].中华肝脏病杂志,2003,11(2):71-71. 被引量：1369
  • 5Sargin M, Uygur-Bayramicli O, Sargin H, et al. Association of nonalcoholic fatty liver disease with insulin resistance: is OGTY indicated in nonalcoholic fatty liver disease [ J ] . J Clin Gastroenterol, 2003,37 (5) : 399-402.
  • 6Marchesini G, Bfizi M, Bianchi G, et al. Nonalcoholic fatty liver disease : a feature of the metabolic syndrome [ J ]. Diabetes, 2001, 50(8) : 1844-1850.
  • 7毕艳.2型糖尿病病人早期胰岛素分泌功能受损的研究进展[J].中国糖尿病杂志,2003,11(1):63-64. 被引量：30
  • 8Biden T J, Robinson D, Cordery D, et al. Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics [J]. Diabetes, 2004, 53 (Suppl 1): S159-S165.

二级参考文献13

  • 1Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type 2 diabetes mellitus. Diabetologia, 2001,44 : 929-945.
  • 2Pratley RE, Hagberg JM, Dengel DR, et al. Aerobic exercise training induced reductions in abdominals fat and glucose stimulated insulin responses in middle aged and older men. J Am Geriatr Soc, 2000,48 : 1055-1061.
  • 3Bergman RN. New concepts in extracellular signaling for insulin action. Recent Prog Horm Res, 1997,52 : 359-385.
  • 4Matsumoto K, Miyake S, Yano M, et al. Glucose tolerance,insulin secretion, and insulin sensitivity in non-obese and obese japanese subjects. Diabetes Care, 1997,20:1562-1568.
  • 5Lehtovirita M, Kaprio J, Forsblom C, et al. Iusulin sensitivity and secretion in monozygotic and dizysotic twins. Diabetolosia,2000,43 : 285-293.
  • 6Mcgarry JD, Dobbins PL. Fatty acids, lipotoxicity and insulin secretion. Diabetologia, 1999,42 : 128-138.
  • 7Paolisso G, Tagliamonte MR, Rizzo MR, et al. Low eating fatty acids potentiates acute insulin response in first degree relatives of people with type 2 diabetes. Diabetologia, 1998, 41:1127-1132.
  • 8Laedtke T, Kjems L, Porksen N, et al. Overnight inhibition of insulin secretion restorese pulsatility and proinsulin/insulin ratio in type 2 diabetes. Am J Physiol,2000,279:E520-E528.
  • 9Heinemann L, Klappoth W, Rave K, et al. Intra-individula variability of the metabolic effect of inhaled insulin together with an absorption enhancer. Diabetes Care, 2000, 23: 1343-1347.
  • 10Todd JF, Edwards CM, Ghatei MA, et al. Subcutaneous glucagons-like peptide-1 improves postprandial glycaemic control over 3 week period in patients with early type 2 diabetes.Clin Sci,1998,95:325-329.

共引文献1400

同被引文献62

引证文献8

二级引证文献70

实用医学杂志
2008年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部