摘要
目的:评价度洛西汀与文拉法辛治疗抑郁症的疗效和不良反应。方法:将符合中国精神障碍分类与诊断标准第三版(CCMD-3)诊断标准的90例抑郁症门诊患者,随机分为两组,度洛西汀组45例和文拉法辛组45例治疗,疗程8周,用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、临床疗效总评量表的病情严重程度(CG I-S1)和副反应量表(TESS)评定疗效,起效时间及不良反应,与文拉法辛相当。结果:度洛西汀治疗抑郁症的临床疗效与文拉法辛相当。结论:度洛西汀是一种安全有效的新一代抗抑郁药,疗效和起效时间与文拉法辛相当,且服用方便,可作为治疗抑郁症的一线药物。
Objective：To compare efficacy and side effects between Duloxetine Hydrochloride Enteric Capsules vs Venlafaxine in the treatment of deoression.Methods：90 inpatients and outpatients with a diagnosis of depression according to CCMD-3 were involved in this study.They were randomly assigned to the Duloxetine Hydrochloride Enteric Capsules group（n=45） and we venlafacine group（n=45） for 8 weeks.Effects and side reactions were evaluated with HAMD.CGI-SI and TESS before and after the treatment.Results： Findings indicatde that efficacy of Duloxetine Hydrochloride Enteric Capsules was similar to than of venlafaxine,howerer Duloxetine Hydrochloride Enteric Capsules took effect more qutckly and its side effects were as little as venlafaxine.Conclusions： Both Duloxetine Hydrochloride Enteric Capsules and Venlafaxine have better efficacy and milder side.Effect in the treatment of depression.Duloxetine Hydrochloride Enteric Capsules is an effective and safe anlidepressant.It is suggested that Duloxetine Hydrochloride Enteric Capsules could be used as a first-line antidepressant in the treatment of depression.
出处
《中国民康医学》
2008年第23期2779-2780,共2页
Medical Journal of Chinese People’s Health
关键词
度洛西汀
文拉法辛
抑郁症
Duloxetine Hydrochloride Enteric Capsules
Venlafaxine
Depression
