摘要
[目的]了解肝硬化患者血小板及其相关参数和凝血指标的变化,探讨其临床意义。[方法]检测62例肝硬化患者血小板参数(PLT、PCT、MPV、PDW)、凝血指标(PT、TT、APTT、FIB),并与50例健康对照组的血小板及其相关参数和凝血指标进行比较,同时肝功能分级后组间血小板及其相关参数也进行了比较。[结果](1)肝硬化组与正常对照组比较,PLT、PCT显著下降,MPV、PDW显著升高;肝功能B、C级与A级比较,C级PLT和PCT下降显著,MPV、PDW显著升高。(2)肝硬化患者PT、TT、APTT均较对照组明显延长,FIB明显降低。[结论]肝硬化患者存在血小板及凝血异常,血小板参数和凝血指标可以反映肝病的肝损程度和病情轻重,指导临床治疗及其预后都具有重要的意义。
[Objective] To analyze the change of platelet parameters and coagulation indices in patients with hepatic cirrhosis. [Methods] The platelet parameters （PLT, PCT, MPV, PDW） and coagulation indices （PT, TT, APTT, FIB） of 62 cases of hepatic cirrhosis and control group were examined and analyzed by t test. [ Results ] （ 1 ） Compared with the control group, PLT, PCT descended evidently and MPV, PDW increased significantly. As the pathogenetic condition was more serious, PLT, PCT were lower and MPV, PDW were higher on B and C stage patients with hepatic cirrhosis than A stage ones. （2） PT, TT, ApTT in 62 cases of pauents were longer than in the control group and FIB descended evidently, and there was obviously different between two groups. [ Conclusion ] There is abnormality of platelet parameters and disturbance of blood coagulation in patients with hepatic cirrhosis, some of platelet parameters and coagulation indices may reflect the pathogenetic condition and damage degree of liver disease.
出处
《现代预防医学》
CAS
北大核心
2008年第23期4749-4750,4756,共3页
Modern Preventive Medicine
关键词
肝硬化
血小板参数
凝血指标
Hepatic cirrhosis
Platelet parameter
Coagulation index
