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国产伏立康唑治疗急性白血病合并侵袭性真菌感染的疗效观察 被引量：3

Effect of Voriconazole in the treatment of acute leukemia patients with invasive fungal infection
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摘要 目的观察国产伏立康唑治疗急性白血病合并侵袭性真菌感染(IFI)的临床疗效和安全性。方法回顾性分析30例急性白血病合并IFI住院患者使用国产伏立康唑治疗的效果。结果国产伏立康唑治疗30例IFI患者的总有效率为53.3%(16/30),5例患者出现不良反应,经处理后全部好转。结论国产伏立康唑是治疗急性白血病合并IFI患者的有效药物,不良反应少,安全性高。 Objective To observe the therapeutic effect and side effect of Voriconazole treating for invasive fungal infections in patients with acute leukemia. Methods Thirty hospitalized acute leukemia patients complicated with invasive fungal infections were treated with Voriconazole, and the clinical data of the patients and the therapeutic effect were analyzed retrospectively. Results The clinical effective rate of Voriconazole was 53.3%. Side effect was found in 5 patients and was cured after therapy. Conclusion Vorieonazole is an effective and safe treatment option for invasive fungal infection in patients with acute leukemia.
作者 张祥忠 许多荣 陈惠珍 童秀珍 彭爱华 张国材 李娟 陈运贤
机构地区 中山大学附属第一医院血液科
出处 《国际内科学杂志》 CAS 2008年第10期559-561,共3页 International Journal of Internal Medicine
关键词 急性白血病 侵袭性真菌感染 伏立康唑 Acute leukemia Invasive fungal infection Voriconazole
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Chamilos G, Lunam M, Lewis RE, etal. Invasive fungal infection in patients with hematological malignancies in a tertiary care cancer center, an autopsy study overa 15-year period (1989-2003). Haematologica, 2006, 91 (7): 986-989.
  • 2黄晓军.血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则(草案)[J].中华内科杂志,2005,44(7):554-556. 被引量：423
  • 3边绿斐,陈少贤.造血干细胞移植的肺部并发症[J].国际内科学杂志,2007,34(2):81-84. 被引量：4
  • 4沈志祥,陈秋生.血液病合并侵袭性真菌感染的临床特点与治疗[J].中华医学杂志,2005,85(21):1447-1448. 被引量：41
  • 5朱静.伏立康唑的药理特性及临床应用[J].天津药学,2007,19(4):48-50. 被引量：15
  • 6Ally R, Schtirmann D, Kreisel W, et al. A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients. Clin Infect Dis, 2001, 33(9) :1447-1454.
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二级参考文献46

  • 1史煜波,李苏娅,金宁宁.伏立康唑和氟康唑对酵母菌的抗菌活性分析[J].现代实用医学,2006,18(12):870-871. 被引量：6
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国际内科学杂志
2008年 第10期

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