摘要
目的:检测生存素(survivin)和血管内皮生长因子(VEGF)在大肠癌组织中的表达,探讨两者与大肠癌临床病理因素之间的关系及两者相互的联系。方法:应用免疫组织化学技术分别检测survivin和VEGF蛋白在60例大肠癌组织和30例癌旁组织中的表达情况,分析两者的表达与临床病理因素之间的关系及两者间相互的联系。结果:①survivin和VEGF在大肠癌组织中均呈强表达,在癌旁组织内弱表达或不表达(P<0.01);②大肠癌组织中survivin的表达与细胞分化程度、淋巴结转移相关(P<0.01),与肿瘤的浸润深度相关(P<0.05);③大肠癌组织中VEGF的表达与细胞分化程度、浸润深度及淋巴结转移相关(P<0.01);④大肠癌中survivin与VEGF的表达呈显著正相关(P<0.01)。结论:①大肠癌中survivin与VEGF的过表达,可能在肿瘤的发展及转移过程中起着重要作用;②联合检测survivin和VEGF的表达情况,可以为临床上评估大肠癌的进展状态、治疗和预后提供重要的理论依据。
Objective： To determine the expression of survivin and VEGF in colorectal cancer （CRC） and evaluate the relationship between their expression and clinicopathological parameters. Methods：Immunohistochemistry was used to determine the expression of survivin and VEGF protein in 60 cases of CRC tissues and 30 cases of adjacent tissues, then the relationship between their expression and elinicopathological parameters were analysed. Results：（1）The expression of survivin and VEGF in CRC tissues were significantly higher than those in adjacent tissues （ P 〈 0. 01 ） ; （2）The expression of survivin was closely associated with lymph node metastasis and cell differentiation degree of CRC （P 〈 0. 01 ）, and were associated with invasive depth of CRC （ P 〈 0. 05 ） ; （3）The expression of VEGF was closely associated with tumor invasive depth,lymph node metastasis and cell differentiation degree of CRC （P 〈 0. 01 ） ;（4）Survivin expression was significantly positively correlated with VEGF expression in CRC（P 〈0. 01 ）. Conclusions：（1）The high expression of survivin and VEGF may play an important roles in development and metastasis of CRC ; （2）To determine the expression of survivin and VEGF simultaneously can provide theoretical basis for the evaluation of development, treatment and prognosis of CRC.
出处
《内蒙古医学院学报》
2008年第5期313-317,共5页
Acta Academiae Medicinae Neimongol
基金
内蒙古自治区人才基金(2002)
