摘要
目的应用实时超声造影技术评价颈动脉粥样硬化斑块显影程度与急性脑血管病的关系。方法使用Sono Vue实时超声造影检查48例患者的颈动脉粥样硬化斑块,其中23例患急性脑血管病,25例无急性脑血管病,根据时间-强度曲线图分析得出粥样硬化斑块显影后峰值强度/显影前强度比值(Post-PI/Pre-I)、斑块显影后峰值强度/颈动脉管腔显影峰值强度比值(Post-PI/Post-PIC),并分析其预测患者发生急性脑血管病截断值以及敏感性、特异性。结果23例急性脑血管病患者中21例显影、无显影2例。25例无急性脑血管病患者粥样硬化斑块显影15例、无显影10例。两组患者粥样硬化斑块显影后峰值强度(Post-PI)[(-51.2±2.8)dB对(-58.7±7.3)dB,P<0.05],粥样硬化斑块显影后峰值强度与显影前强度比值(Post-PI/Pre-I)(0.78+0.04对0.90±0.03,P<0.05),斑块显影后峰值强度与颈动脉管腔显影峰值强度比值(Post-PI/Post-PIC)(1.28±0.06对1.46±0.21,P<0.05)均有显著性差异。以粥样硬化斑块显影后峰值强度与显影前强度比值(Post-PI/Pre-I)<0.82为截断值预测患者发生急性脑血管病敏感性为76.9%,特异性为64.1%,以斑块显影后峰值强度与颈动脉管腔显影峰值强度比值(Post-PI/Post-PIC)<1.35预测患者发生急性脑血管病敏感性为84.6%,特异性为60.4%。结论超声造影能实时观察颈动脉粥样硬化斑块内的显影情况,并与急性脑血管病发生有关联。
Objective To evaluate the relationship between enhancement of carotid atherosclerotie plaques and the acute cerebrovascular disease （ACD） by contrast-enhanced ultrasonography with SonoVue. Methods Forty-eight patients with carotid atherosclerotic plaques were examined with contrast-enhanced ultrasonography. Of these patiens, 23 suffered from ACD, 25 patients had no acute cerebrovascular disease. The post-enhancement peak intensity in the plaque （Post-PI）, the ratio of post-enhancement peak intensity to pre-enhancement intensity in the plaque （Post-PI/Pre-I）, the ratio of post-enhancement peak intensity to post-enhancement peak intensity in the carotid cavity （Post-PI/Post：PIC） were measured and calculated from the time-intensity curve. Receiver-operating characteristic curves were constructed to evaluate the accuracy of enhancement of atherosclerotic plaques in predicting acute cerebrovascular disease. Results Contrast ultrasonography showed enhancement of the carotid plaque in 21 of 23 patients with ACD, while the carotid plaques were enhanced only in 15 of 25 patients without ACD. There were significant difference between two groups in Post-PI[（-51.2±2.8）dB vs （-58.7±7.3）dB, P〈0.05], Post-PI/Pre-I （0.78±0.04 vs 0. 90±0. 03, P〈0.05） and Post-PI/Post-PIC （1.28±0.06 vs 1.46±0. 21, P〈0. 05）. A cutoff value of Post-PI/Pre-I〈0.-82 as a predictor of ACD had a sensitivity and specificity of 76.9% and 64.1%, respectively. Similarly, a cutoff value of Post-PI/Post-PIC〈1. 35 showed sensitivity and specificity of 84.6% and 60.4%, respectively. Conclusion Contrast-enhanced uhrasonography provides a new way to observe the neovaseularization of the carotid plques. The enhancement of the carotid plaquemay be related with the onset of ACD.
出处
《中国医学影像技术》
CSCD
北大核心
2008年第10期1583-1585,共3页
Chinese Journal of Medical Imaging Technology
关键词
超声检查
造影剂
颈动脉疾病
脑血管病
Utrasonograph
Contrast media
Carotid arteriesdiseases disease
Cerebrovaseular disease
