摘要
动物模型研究显示，脑缺血再灌注时，基质金属蛋白酶（MMP）表达异常，提示其与脑缺血再灌注损伤有关，尤其是MMP-2、MMP-3和MMP-9，在急性缺血性脑血管病的发病机制中起着重要作用。了解MMP在脑缺血再灌注损伤中的表达、作用、影响其表达的因素及有关抗体的研究和应用，可为脑梗死的早期诊断、预防和治疗提供一种新的选择。
The studies of animal models have shown that the expression of matrix metalloprotease （MMP） is abnormal during cerebral ischemia/reperfusion, which indicating that it is associated with cerebral ischemia/reperfusion injury, especially MMP-2, MMP-3 and MMP-9 play the important roles in the pathogenesis of acute ischemic cerebrovascular disease. Understanding of the roles and expressions of MMP, the factors affecting its expression, and the studies and application of the related antibodies in cerebral ischemic/reperfusion injury may provide a new alternative for the early diagnosis, prevention and treatment of cerebral infarction.
出处
《国际脑血管病杂志》
2008年第9期703-706,共4页
International Journal of Cerebrovascular Diseases
关键词
基质金属蛋白酶
脑缺血
血脑屏障
matrix metalloproteinase
cerebral ischemia
blood-brain barrier
