摘要
【目的】探讨抑郁症患者在愉快和悲伤面部表情刺激下的脑功能机制。【方法】对20例首发未服药重性抑郁症患者和20例正常人进行愉快和悲伤面部表情刺激下的脑功能磁共振成像研究。【结果】在愉快和悲伤表情刺激下,相对正常对照,重性抑郁症患者主要表现在前额脑区(包括前扣带)和边缘脑区(海马、海马旁回、杏仁核)的激活。【结论】前额和边缘脑区的损害可能参与了重性抑郁的病理生理机制。
[Objective]To study the mechanism of cerebral functional magnetic resonance imaging（fMRI） in patients with first episode psychotic depression under stimulation of happy and sad facial expression. [Methods]Neural responses to happy and sad facial expression stimuli were measured by fMRI in 20 cases with first psychotic depression and 20 healthy controls. [Results]Compared with healthy controls, patients with psychotic depression presented the activation in prefrontal area （prefrontal cingulate gyrus） and marginal brain area（hippocampus gyrus, para-hippoeampus and amygdala） [Conclusion]The damage of prefrontal and marginal areas may involve the mechanism of pathophysiology in psychotic depression.
出处
《医学临床研究》
CAS
2008年第10期1736-1738,1743,共4页
Journal of Clinical Research
基金
湖南省卫生厅基金项目资助(B2005106)
湖南省自然科学基金项目资助(07JJ3042)
关键词
抑郁症
面部
磁共振成像
depression
face
magnetic resonance imaging
