摘要
目的根据WHO胸腺上皮肿瘤(TET)最新分类标准,研究Bmi-1、Podoplanin和p53在TET中的表达及临床意义。方法采用组织芯片技术制作110例TET组织芯片,免疫组化NovoLinkTMPolymer法检测TET中Bmi-1、Podoplanin和p53的表达情况。结果在110例TET中,Bmi-1的阳性表达率为68.2%,Podoplanin的阳性表达率为41.8%,p53的阳性表达率为42.7%。Bmi-1、Podoplanin和p53的阳性表达率与TET的病理组织学分型、Masaoka分期及临床病理分级等有显著相关性(P<0.05),而且Bmi-1和p53的表达呈正相关(r=0.941,P=0.005)。结论Bmi-1、Podoplanin和p53在TET的发生发展中起着重要作用,对指导临床治疗和预后评估有着重要参考价值。
Objective To investigate the expression and clinical significance of Bmi-1, Podoplanin and p53 in human thymie epithelial tumor（TET） according to new histological classification of World Health Organization. Methods One hundred and ten TET tissue chips were prepared, and the expressions of Bmi-1, Podoplanin and p53 were detected by NovoLinkTM Polymer detection systems. Results The positive expressions of Bmi-1, Podoplanin and p53 were 68.2% , 41.8% and 42.7% , respectively. The positive expressions of Bmi-1, Podoplanin and p53 were significantly associated with pathologic histological classification, Masaoka staging and clinic pathological grading （P 〈0.05）. Besides, the expression of Bmi-1 was positively correlated to that of p53 （ r = 0. 941, P = 0. 005 ）. Conclusion The expressions of Bmi-1, Podoplanin and p53 play an important role in the pathogenesis and progression of TET, which are helpful markers in the treatment and prognostic prediction of TET.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2008年第9期1130-1133,共4页
Journal of Shanghai Jiao tong University:Medical Science
