摘要
目的评价雷贝拉唑和莫沙必利联合应用治疗老年人非糜烂性反流病(NERD)的疗效。方法对52例NERD老年患者在应用雷贝拉唑和莫沙必利联合治疗前后的临床表现、24h食管pH监测值的变化情况及不良反应进行比较。结果用药前及用药后每2周进行临床症状观察,发现治疗后临床症状逐渐改善及消失,24h食管pH监测各项指标在治疗后均明显小于治疗前(P<0.01);两药联用未见明显不良反应。结论雷贝拉唑联合莫沙必利治疗老年NERD疗效确切。
OBJECTIVE To evaluate the effect reflux disease （NERD） in the elderly. METHODS of combined using rabeprazole and mosapride for non-erosive Fifty-two elderly patients suffering from NERD were enrolled. All patients received rabeprazole and mosapride. The clinical manifestations, 24-hour esophageal pH monitoring and the adverse reactions before and after treatment were compared. RESULTS The clinical symptoms had marked changes after treatment by rabeprazole and mosapride. The index of 24-hour esophageal pH had obviously improved with significant difference （P 〈 0.01）. There were no marked adverse reactions during the thera- py. CONCLUSION There was definite effect of combined rabeprazole and mosapride therapy for NRED in the elderly and no adverse reaction.
出处
《海峡药学》
2008年第8期100-102,共3页
Strait Pharmaceutical Journal
关键词
非糜烂性反流病
老年
雷贝拉唑
莫沙必利
Non-erosive reflux disease（NERD）
Elderly
Rabeprazole
Mosapride
