摘要
在玻碳电极上成功地制备了多壁碳纳米管修饰电极(MWCNTs/GCE-CME)。研究了双嘧达莫(DPD)在该修饰电极上的电化学行为。基于表面活性效应,得知十二烷基磺酸钠(SDS)可提高DPD在MWC-NTs/GCE-CME的氧化电流,修饰电极对其具有明显的增敏作用,并对存在的机理作了探讨。在SDS介质存在下,通过DPD在MWCNTs/GCE-CME上的氧化和高锰酸钾在另一电极上的还原构建不可逆双安培检测体系,建立直接测定DPD的新方法。在0.05mol/LH2SO4介质中,DPD氧化峰电流与其浓度在1.5×10-6～1.0×10-3mol/L范围内呈线性关系(r=0.9950,n=16);线性回归方程为i(nA)=2.37×106C-450;方法检出限为8.0×10-7mol/L;电流值RSD为1.8%;进样频率为80样/h。本方法具有较高的选择性和灵敏度,样品处理方法简单快速,适合于实时在线分析。修饰电极易于制作,具有良好的稳定性和重现性及抗干扰性能,对DPD片剂测定结果满意。
The multi-wall carbon nanotubes-modified glassy-carbon electrode （MWCNTs/GCE-CME） was prepared at the bare glassy-carbon electrode, and the micrographs of the MWCNTs/GCE-CME were obtained by scanning electron microscopy. The electrochemical behaviors of dipyridamole （DPD） on the modified electrode were studied. The oxidation peak current of DPD at the MWCNTs/GCE-CME increases significantly under the effect of enhancement of SDS surfactant in comparison to that at the bare GCE. The reaction mechanism was investigated. An irreversible system was established to analysis the DPD which is composed of oxidation of DPD at MWCNTs/GCE-CME and reduction of permanganate at the other electrode within the SDS medium. In the 0.05 mol/L H2SO4 , the oxidative peak current increases linearly with the concentration of DPD in the range of 1.5 × 10^-6 - 1. 0 × 10^-3 mol/L, linear regression equation： i（nA） = 2.37 × 10^6C -450, with a sampling frequency of 80 samples per hour. The detection limit for DPD is 8.0 × 10^ -7 mol/L and the RSD is 1.8%. This proposed method has the advantage of high selectivity and sensitivity. It is suitable for on-line analysis. The method has been applied to the analysis of DPD tablet with satisfactory results.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2008年第8期1077-1082,共6页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金(No.20665001)
广西科学基金(0640029)
广西工学院硕士基金(No.500572)资助
关键词
多壁碳纳米管
表面活性剂
化学修饰电极
不可逆双安培法
双嘧达莫
Multi-wall carbon nanotubes, surfactant, chemically modified electrode, irreversible biamperometry, dipyridamole
