摘要
通过微波辐射,苯并咪唑与多种卤素取代的芳基化合物在催化剂碘化亚铜、配体L-脯氨酸或N,N-二甲基甘氨酸的存在下,以二甲基亚砜作溶剂,在较低温度(75～110℃)下一步合成,得到6种高产率的1-芳基取代苯并咪唑衍生物为该类化合物的合成提供了一种新方法.产物通过熔点测定,核磁共振氢谱、核磁共振碳谱、质谱等的表征.
The copper-catalyzed Ullmann-coupling reaction of benzimidazole with （un）substituted pnenyl halide gave benzimidazole derivatives in good to excellent yields in DMSO at 75-110 ℃ under microwave irradiation conditions by using either L-proline or N,N-dimethylglycine as a ligand. This method provides a simple and inexpensive access to the title compounds. The structures of the products were confirmed by melting points, ^1H NMR, ^13C NMR and EI-MS spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第7期1278-1281,共4页
Chinese Journal of Organic Chemistry
基金
浙江省自然科学基金(No.202075)
浙江省有机化学重点学科建设(No.020101)资助项目
关键词
微波
苯并咪唑
芳基卤化物
偶联反应
microwave
benzimidazole
（un）substituted phenyl halide
Ullmann-coupling reaction
