摘要
背景与目的肺癌诊治中目前缺乏特异性指标,本研究旨在初步探讨hnRNP K蛋白在肺癌中的表达及意义。方法采用SP免疫组织化学方法检测70例肺癌组织及27例对照肺组织中hnRNP K的表达。结果免疫组化显示肺癌组织hnRNP K阳性率为64.9%(76/117),高于非肺癌组织33.3%(9/27)(P<0.001),并且在胞浆、胞核均有表达。三种类型肺癌组织均有hnRNPK阳性染色。其中小细胞肺癌(small cell lung cancer,SCLC)阳性率73.7%(14/19)与非小细胞肺癌(non-small cell lung cancer,NSCLC)阳性率54.9%(28/51)相比,组间无统计学差异(P>0.05)。结论证实hnRNP K在肺癌组织中呈高表达,但与肺癌组织类型无明显关系。
Background and objective There is no any specific criterion in early diagnosis of lung cancer yet. The aim of this study is to determine hnRNP K expression in lung cancer tissues and normal lung tissues and to provide data for the diagnosis and treatment of lung cancer. Methods The expression of hnRNP K was studied by using the SP method of immunohistochemistry in lung tissue samples of 70 cases of lung cancer and 27 cases of control groups. Results The positive rate of hnRNP K was 64.9% （76/117） in lung cancer tissues , which was significantly higher than that in control group （33.3%, 9/27） （P〈0.001）. hnRNP K was localized in the cytoplasm and/or nucleus. Three subtypes of lung cancer all showed positive staining of hnRNP K protein. The positive rate of hnRNP Kwas 73.7% （14/19） in SCLC and 54.9% （28/51） in NSCLC （P〉0.05） . Conclusion hnRNP K can highly express in lung cancer tissues , but it does not correlate with histological classification of lung cancer.
出处
《中国肺癌杂志》
CAS
2008年第2期241-245,共5页
Chinese Journal of Lung Cancer
关键词
HNRNP
K
肺肿瘤
免疫组化
Heterogeneous-nuclear ribonueleoprotein K Lung neoplasms Immunohistochemistry
