摘要
目的探讨CD147及Ⅳ型胶原在胆囊癌中表达及二者的关系。方法应用免疫组织化学S-P法检测32例胆囊癌组织及25例胆囊炎组织中CD147和Ⅳ型胶原的表达情况。结果CD147在胆囊癌组中的阳性表达率明显高于胆囊炎组(P<0.01),而Ⅳ型胶原在胆囊癌组中的阳性表达率显著低于胆囊炎组(P<0.01);胆囊癌中CD147及Ⅳ型胶原的表达具有负相关性(P<0.01)。结论胆囊癌组织中CD147的高表达和Ⅳ型胶原低表达及二者的负相关性,可以作为胆囊癌基础和临床研究的客观参考指标。
Objective To investigate the expressions of CD147 and Collagen Ⅳ and their relationship in gallbladder cancer. Methods the expressions of CD147 and Collagen Ⅳ were examined by immunohistochemical S-P stainingmethod in 32 cases with gall- bladder cancer and 20 cases with choleeystitis tissues. Results The expression rates of CD147 in gallbladder cancer were significantly higher than those in eholeeystitis （P 〈 0. 01 ） ; however, The expression rates of Collagen Ⅳ in gallbladder cancer were significantly lower than those in eholeeystitis （ P 〈 0. 01 ）. There was a significant negative correlation between the expressions of CD147 and Collagen Ⅳ in gallbladder cancer （P 〈0. 01 ）. Conclusions The high expressions of CD147 and the low expressions of Collagen Ⅳ and their negative correlation may be used as one of the marks to study gallbladder cancer.
出处
《肝胆外科杂志》
2008年第3期227-229,共3页
Journal of Hepatobiliary Surgery
