摘要
目的观察固本喘嗽康颗粒对哮喘的药效作用。方法通过动物模型引咳、祛痰和引喘实验来观察其镇咳、祛痰、平喘效果。结果高、中、低剂量的固本喘嗽康颗粒均能显著地抑制浓氨水所致小鼠咳嗽潜伏期和咳嗽次数;能增加小鼠呼吸道的酚红排泌量;还能显著地延长豚鼠哮喘潜伏期,对豚鼠离体气管平滑肌痉挛具有明显的松弛作用。结论固本喘嗽康颗粒具有明显的镇咳、祛痰、平喘作用。
Objective To observe the pharmacodynamic function of Gubenchuansoukang granules on asthma.Methods We observed the antitussive,apophlegmatic and antiasthmatic effect of the granules on such points as cough-inducing,asthma-inducing,and eliminating phlegm through mouse models.Results Hight,middle and low dose of Gubenchuansoukang granules were able to prolong cough latent period,decrease cough rate significantly in mice induced by ammonia solution,and increase the excretion of phenolsulfonphthalein in the trachea of mice.It could also prolong tussive latent period resulted from histamine phosphate in guinea pigs significantly,and relax the bronchus smooth muscles markedly in guinea pigs.Conclusion Gubenchuansoukang granules are antitussive,apophlegmatic and antiasthmatic.
出处
《中南药学》
CAS
2008年第3期277-280,共4页
Central South Pharmacy
关键词
固本喘嗽康
哮喘
实验研究
Gubenchuansoukang granule
asthma
experimental study
