摘要
目的采用回顾性研究方法分析齐多夫定、奈韦拉平联合用药与单剂量奈韦拉平用药方案在预防艾滋病母婴传播中对肝功能和血象的影响。方法于2005年5月至2006年10月,对人类免疫缺陷病毒感染的孕产妇109例、婴儿82例应用齐多夫定和奈韦拉平联合用药及单剂量奈韦拉平用药方案的情况进行分析;以第6版医学教材中的血象、肝功正常值为参照进行比较;以国际治疗艾滋病药物毒性指南判定肝功的损害程度。结果在齐多夫定、奈韦拉平联合用药方案中,母亲服药前后血红蛋白、红细胞平均血红蛋白、总胆红素发生改变,新发贫血15例,但未见粒细胞减少病例;婴儿贫血3例、血小板减少2例、粒细胞减少4例;采用单剂量奈韦拉平用药方案中,母亲产时(服药前)和产后42天的总胆红素、直接胆红素、谷丙转氨酶发生改变;婴儿在出生后6个月出现贫血3例,血小板减少3例,粒细胞减少3例。两种方案进行比较,孕产妇产后42天和婴儿出生后3个月肝功各项指标及婴儿出生后6个月红细胞、血红蛋白、血小板均无统计学意义(P>0.05)。结论两种方案均对母婴血液系统、肝功系统的影响不大。
Objective To observe and compare adverse effects of combination of zidovudine （AZT） with nevirapine （NVP） regimen and single NVP regimen in preventing mother-to-child transmission of HIV. Methods The regimens of combination of AZT with NVP and single NVP for 109 pregnant wgmen and 82 infants with HIV infection/AIDS from May 2005 to October 2006 were retrospectively evaluated. The hemogram results of all subjects were assessed by normal reference values from the sixth edition of medical textbook. The severity of impirement of liver function was determined according to International Toxicity Guidelines of Anti-AIDS Drugs for Adults and Children. Results Combination regimen： hemaglobulin （ HB）, RBC mean hemoglobulin, total bilirubin of those mothers varied after receiving combination antiretroviral regimen, 15 subjects developed new anemia, but no granulocytopenia was found, 3 infants developed anemia, 2 infants developed thrombopenia and 4 infants developed granulocytopenia. Single NVP regimen ： the maternal levels of total bilirubin, direct bilirubin and ALT changed as compared those in delivery （before antiretroviral therapy） with those at the 42th postpartum day. 3 infants who received single NVP regimen developed anemia, 3 infants developed thrombopenia and 3 infants developed granulocytopenia. There were no significant differences in liver function indexes of parturient women at the 42th postpartum day and the 3rd months of age of infants and RBC, Hb, PLt of infants at their 6 months of age between the combination regimen and single NVP regimen （ all P 〉 0. 05 ）. Conclusion The effects of the two regimens on hemogram and liver function of the mothers and the infants are not significant.
出处
《中国妇幼健康研究》
2008年第3期202-205,共4页
Chinese Journal of Woman and Child Health Research
基金
国家科技攻关计划课题资助项目(2004BA719A14-7)
关键词
艾滋病
母婴传播
抗逆转录治疗
副作用
AIDS
mother-to-child transmission
anfiretroviral therapy
adverse effect
