摘要
目的了解P53基因在泪腺肿瘤的表达及其临床病理学意义。方法应用免疫组织化学ABC法检测57例泪腺上皮性肿瘤患者和10例正常人泪腺组织中P53蛋白的表达情况，并与病理分级、复发相联系。结果10例正常人泪腺组织中P53表达全部为阴性；恶性肿瘤患者的表达率为48．6％，良性肿瘤中P53达率为18％，二者相比有显著性差异（P＜0．025）；复发患者阳性率为76．9％，明显高于未复发患为31．8％（P＝0．015）。结论P53基因参与了泪腺肿瘤的发生发展并与肿瘤的分化和复发有关。
To evaluate the relationship between the expression of P53 protein and clinical pathology in patients withthe lacrimal gland tumor.Methods: The expression of P53 protein was measured in 57 epithelial tumors of lacrimal gland and 10 normal controls by using ABC immunoperoxidase technique.Results: P53 protein staining in 10 controls was negative. The expression rate of P53 protein (48. 6% ) in malignant group was markedly higher than that in benign tumor(18%, P＜0. 0250). Compared with the non - recurrence,the patients with the recurrence of tumor had a overexpres.sion (P=0. 015 ).Conclusion: The P53 gere involves occuring of the epithelialtumor of the lacrimal gland and is related to aseurrence of tumor.
出处
《眼科新进展》
CAS
1997年第4期197-199,共3页
Recent Advances in Ophthalmology
