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急性白血病患者外周血CD4^＋CD25^＋FOXP3^＋调节性T细胞的检测 被引量：5

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摘要 1995年Sakaguchi等首次报道在正常小鼠外周血CD4^＋T细胞中约有5％～10％的细胞持续高表达CD25分子，称之为CD4^＋CD25^＋调节性T细胞（CD4^＋CD25^＋Treg）。研究发现CD4^＋CD25^＋Treg通过细胞．细胞直接接触，也可通过分泌IL-10和TGF-β而对局部免疫反应产生抑制作用。目前已证实在卵巢癌、肺癌、乳腺癌、胰腺癌、结肠癌、肝癌等多种实体肿瘤患者外周血中CD4^＋CD25^＋Treg比例增高，
作者 张帆 王宏伟 樊卫平 徐菁 朱镭
机构地区 山西医科大学第二医院血液病研究所 山西医科大学微生物与免疫教研室 山西医科大学病理学教研室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第5期346-347,共2页 Chinese Journal of Hematology
关键词 调节性T细胞 鼠外周血 急性白血病患者 CD4^+T细胞 CD25分子 检测 局部免疫反应 TGF-Β
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献8

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二级参考文献3

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共引文献5

同被引文献38

  • 1李爱华,曹祥山,邱国强,顾伟英,凌云,翁开枝,谭琪.CD4^+CD25^+Foxp3^+调节性T细胞在急性白血病患者外周血的表达[J].江苏医药,2007,33(8):775-777. 被引量：2
  • 2Shevach EM.Mechanisms of Foxp3(+) T regulatory cell-mediated suppression.Immunity,2009,30:636-645.
  • 3Cao T,Soto A,Zhou W,et al.Ex vivo expanded human CD4^+ CD25^+ FOXP3^+ regulatory T cells prevent lethal exnogenic graft versus host disease(GVHD].Cell Immunol,2009,258:65-71.
  • 4Shevaeh EM,Mchugh RS.Picirillo CA,et al.Control of T cell activation by CD4+ CD25+ suppressor T cells.J Immmunol Rev,2001,103:449-457.
  • 5楼瑾,汪明春,李明,聂李平.急性非淋巴细胞白血病患者NK细胞亚群及其NCR受体测定[J].中国病理生理杂志,2007,23(10):2063-2064. 被引量：9
  • 6Balzasina B,Piconese S,Guiducci C,et aI.Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25+ lymphocytes is thymus and proliferation independent[J]. Cancer Ees, 2006,66. 4488-4498.
  • 7Schramm C, Huber S, Protschka M, et al. TGFbeta regulates the CD4 + CD25 + T-cell pool and the expression of Foxp3 in vivo[ J]. Int Immunol,2004,16(9) :1 241 - 1 249.
  • 8Beyer M, Kochanek M, Darabi K, et al. Reduced frequencies and suppressive function of CD4 + CD25 regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine [ J ]. Blood,2005,106 (6) :2 018 - 2 025.
  • 9Wu C, Wang S, Wang F, et al. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia[ J ]. Clin Exp Immunol,2009,158 (2) :199 -204.
  • 10Zhang Q, Wang HY, Woetmann A, et al. STAT3 induces transcription of the DNA methyhransferase 1 gene (DNMTI) in malignant T lymphocytes [ J ]. Blood, 2006, 108 ( 3 ) : 1 058 -1 064.

引证文献5

二级引证文献16

中华血液学杂志
2008年 第5期

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