摘要
目的探讨益气养阴、解毒活血组方对冠心病患者血小板活化、内皮功能紊乱和炎症反应相关指标的影响。方法将86例冠心病患者随机分为益气养阴、活血解毒组(治疗1组)、益气养阴组(治疗2组)及对照组,观察患者治疗前后血浆中血管性假性血友病因子(vWF)、α颗粒膜蛋白140(GMP-140)、血清C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)含量变化。结果治疗后治疗1组vWF、GMP-140、CRP、TNF-α、IL-6含量均明显低于其他组(P<0.05)。结论益气养阴、解毒活血方治疗冠心病能起到改善其内皮细胞损伤、抑制血小板活化、抗动脉炎症反应、改善动脉硬化的作用。
Objective To study the effect of prescriptions of reinforcing qi,replenishing yin,activating blood and removing toxins on the platelet activation,vessel endothelial disorders and inflammatory reactions in coronary heart disease patients. Methods The 86 patients were randomized into the group of reinforcing qi,replenishing yin,activating blood and removing toxins （treatment group 1）, the group of reinforcing qi and replenishing yin （treatment group 2）,and the control group. Before and after treatment,the level of plasma von willebrand factor （vWF）,alpha-granular membrane protein （α-GMP-140）,serum C-reactive protein （CRP）,tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） was measured respectively. Results After treatment, vWF,α GMP-140,CRP,TNF-α and IL-6 of treatment group 1 were significantly lowered than those of other groups（P〈0. 05）. Conclusion The prescriptions of reinforcing qi,replenishing yin,activating blood and removing toxins can obviously repair the endothelial injuries,inhibit the platelet activation ,resist the arterial inflammatory reactions ,and improve the arteriosclerosis.
出处
《中医杂志》
CSCD
北大核心
2008年第4期317-319,共3页
Journal of Traditional Chinese Medicine
关键词
血管性假性血友病因子
α颗粒膜蛋白140
C反应蛋白
肿瘤坏死因子
白细胞介素6
益气养阴
活血解毒
von willebrand factor （vWF）i alpha-granular membrane protein （a-GMP-140）~ Serum C-reactive protein （CRP）~ Tu-mor necrosis factor-α （TNF-α）
Interleukin 6 （IL-6）
Reinforcing qi,replenishing yin,activatining blood and removing toxins
