摘要
为观察不同方案对十二指肠溃疡患者幽门螺杆菌（Ｈｐ）的根除效果及其再感染与溃疡复发的关系，对８８例Ｈｐ阳性的十二指肠溃疡患者分组治疗并随访观察。结果：雷尼替丁＋羟氨苄青霉素＋甲哨唑，铋剂＋甲哨唑＋四环素和奥美拉唑＋羟氨苄青霉素对Ｈｐ的根除率分别是９２．９％、８１．３％和７６．９％；对十二指肠溃疡的４周愈合率分别是８５．７％、８１．３％和９２．３％。平均随访１２．４±３．１月，Ｈｐ未根除的３２例中２９例复查，溃疡复发１４例；Ｈｐ已根除的５１例中复查４５例，除１例溃疡复发与非甾体类消炎药相关外，６例复发与Ｈｐ再感染有关，１年总的Ｈｐ再感染率２０．０％。结果提示：根除Ｈｐ可防止十二指肠溃疡复发。
The aim of this study was to determine the eradication of Helicobacter pylori(Hp) with different antimicrobial regimens and the incidence of reinfection in duodenal ulcer patient whose Hp had been eradicated.Eightyeight patients with Hp positive duodenal ulcer were treated, and followed up for 124±31 months in average on Hp status (urease reaction, histological test, and 14C urea breath test) and ulcer relapse (endoscopy). Results:with completed 2 weeks therapy, eradication of Hp in group 1( bismuth, metronidazole+ tetracycline), group 2(ranitidine, amoxicillin+metronidazole) and group 3(omeprazole plus amoxicillin) were 813%,929% and 769%, respectively,while the healing rate for bisumth, ranitidine and omeprazole were 813%,857% and 923% at the end of 4 weeks, respectively.Fourteen of 29 patients in the noneradicated group experienced ulcer relapse(483%),while 7 of 45 cases in the eradicated group ulcer relapsed, of which 6 patients were associated with Hp reinfection (133%).Nine patients (200%) in the eradicted group were reinfected.It is concluded that eradication of Hp infection leads to striking reduction in duodenal ulcer relapse, which are mostly associated with Hp reinfection.
出处
《中华消化内镜杂志》
1997年第6期351-353,共3页
Chinese Journal of Digestive Endoscopy
