摘要
用改良的直接法分析了20例大肠癌新鲜瘤组织及4例大肠癌细胞系的细胞遗传学改变，发现瘤细胞多为异倍体，染色体众数以亚二倍体居多；核型分析发现，其杂色体数目畸变为，13号染色体增多；17号、1号和Y染色体的丢失，结构畸变最常累及1号染色体，断裂声、1q21出现率较高，其次为1p13区的断裂及末端丢失。提示1号染色体结构异常可能为原发性大肠癌特征性染色体改变之一。
A modified technic of direct chromosome preparation was employed in the cytogenetic study of 20 cases of colorectal cancer and 4 cell lines. It was indicated that most of the tumor cells were heteroploids. The chromosome number was predominantly hypodiploid. Karyotypic analysis demonstrated that gain of chromosome 13 and loss of chromosomes 17, 1 and Y occurred more frequently.The structural abnormality by and large involved chromosome 1. The breakpoint lq21 occurred in great frequency. Next to these the breakage and terminal deletion were commonly observed in band lp13. It is suggested that the structural aberration of chromosome 1 might be regarded as the characteristic chromosome rearrangement in colorectal cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第9期658-661,共4页
Chinese Journal of Clinical Oncology
关键词
肠肿瘤
染色体
细胞遗传学
Colon cancer Chromosome Cytogenetics Karyotypic analysis
