摘要
目的探讨不同病理前列腺组织中雄激素受体(AR)、糖皮质激素受体(GR)的表达变化及与前列腺癌生物学行为的关系。方法选取15例人正常前列腺(NP)组织、25例良性前列腺增生(BPH)组织、57例前列腺癌(PCa)组织,对PCa进行Gleason分级,并根据临床雄激素阻断治疗效果分为雄激素依赖组(ADPC,n=39)和雄激素非依赖组(AIPC,n=18),免疫组化检测手术标本AR、GR、PSA的表达并分析其与Gleason分级的关系。结果从NP、BPH到ADPC组织,AR表达呈逐渐升高趋势,而GR表达呈逐渐降低趋势,当进展到AIPC时,AR表达明显降低,GR表达明显升高(P<0.05)。随着Gleason分级的增高,AR表达逐渐降低,GR表达逐渐升高(P<0.05)。结论GR抑制了前列腺癌细胞的分化,长期雄激素阻断治疗导致AR表达降低,GR表达升高,AR/GR信号途径失衡是前列腺癌雄激素非依赖进展的重要原因。
Objective To explore the variation of androgen receptor （AR） and glucocorticoid receptor （GR） in prostate tissues and the relation to biological behavior of prostate cancer （PCa）. Methods Total 57 cases of PCa were graded according to Gleason score and were divided into androgen dependent PCa （ ADPC, n = 39） and androgen independent PCa （ AIPC, n = 18） according to clinical effect of androgen - ablation. The expression of AR and GR protein were detected by immunohistochemistry in tissue specimens obtained from PCa patients by operation and the relation between the expressions of AR and GR and Gleason （NP） and 25 cases of benign prostatic hyperplasia grade was analyzed, with 15 cases of normal prostate （BPH） tissues as control. Results The expression of AR decreased gradually and GR increased gradually from（ NP）, BPH to ADPC tissues, But the expression of AR decreased in AIPC significantly and GR expression increased significantly （ P 〈 0. 05 ）. The expression of AR decreased and GR increased gradually with increase of Gleason grade in PCa tissues （P 〈 0. 05 ）. Conclusion GR may inhibit the differentiation of PCa cells, decreased AR expression and increased GR expression and the loss of equilibrium between AR and GR signal transduction pathway is an important cause for the progression of ADPC to AIPC after androgen - ablation.
出处
《医药论坛杂志》
2008年第5期13-15,共3页
Journal of Medical Forum
关键词
前列腺癌
雄激素受体
糖皮质激素受体
Prostate Cancer
Androgen Receptor
Glucocorticoid Receptor
