摘要
目的通过检测女性压力性尿失禁（SUI）患者尿道周围组织耻骨宫颈筋膜中结缔组织生长因子（CTGF）和p27的表达水平，分析他们与SUI发病以及临床分级之间的关系。方法应用免疫组织化学SP法检测59例SUI（Ⅰ、Ⅱ、Ⅲ度）患者以及23例对照组患者耻骨宫颈筋膜中CTGF及p27的表达水平并进行统计学分析。结果SUI患者耻骨宫颈筋膜组织中p27表达增高，与对照组比较差异有统计学意义（P〈0．01）；随着临床分级的加重p27的表达增强，且组间差异有统计学意义。而SUI患者耻骨宫颈筋膜组织中CTGF表达显著低于对照组患者（P〈0．01）；随着临床分级的加重CTGF的表达减弱，组间差异有统计学意义。SUI患者宫颈筋膜组织中p27、CTGF表达呈负相关（r=-0．918，P〈0．01），且与SUI的临床分级相关。结论在SUI患者耻骨宫颈筋膜中p27的高表达及CTGF的低表达可能在SUI的发生发展中起重要的作用，并与临床分级有关。
Objective To investigate the expression of connective tissue growth factor （CTGF） and p27 in pubocervical fascia of urethra surroundings tissue of stress urinary incontinence （SUI） so as to determine the alteration that contributes to SUI and clinical degree. Methods Biopsy specimens of vaginal wall tissue from 59 women with stress urinary incontinence were collected, with matched specimens from 23 female patients without SUI. Immunohistochemical technique was applied to detect the expression of CTGF and p27. Results SUI group demonstrated a significant increase in p27 expression and a decrease in CTGF expression, with significant difference in comparison to control group and between groups of different degree. Conclusion The high expression of p27 and low expression of CTGF in pubocervical fascia of patients with SUI may contribute to the pathogenesis of SUI and relate to clinical degree.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2008年第2期248-250,共3页
Chinese Journal of Experimental Surgery
基金
湖北省科技攻关项目资助（30113078）
关键词
尿失禁
压力性
结缔组织生长因子
P27
Urinary incontinence, stress
Connective tissue growth factor
p27
