摘要
目的：研究大黄对胃肠动力学的影响。方法：对动物模型（内毒素性休克大鼠）和临床病例进行了监测。结果：内毒素明显抑制肠道跨膜电位〔正常对照组（５９．６３±０．６５）ｍＶ，内毒素休克组（５５．５１±１．５３）ｍＶ〕有显著性差异；大黄可提高内毒素性休克大鼠肠道跨膜电位（５９．３４±０．８７）ｍＶ。临床３６例应激性胃肠粘膜病变伴出血患者经大黄治疗后，３０例显效（其中１８例止血效果良好），６例发生再出血；８例应用Ｈ２受体阻滞剂止血，２例显效，后均发生再出血；１２例采用Ｈ２受体阻滞剂配合冰盐水加去甲肾上腺素（ＮＥ）止血，５例显效，以后均发生再出血。４９例中毒性肠麻痹患者经大黄治疗后，４１例恢复肠蠕动，其中２４例能耐受２０９０ｋＪ／ｄ以上的要素饮食；而２７例应用Ｈ２受体阻滞剂的患者，无一例恢复肠蠕动。结论：大黄能提高胃肠道平滑肌的兴奋性，促进胃肠蠕动，对应激性胃肠粘膜病变亦有较好的疗效。
Objective:To study the effect of rhubarb on gastrointestinal dynamics.Methods:Animals subjected to endotoxic shock and patients suffered from gut failure were included in this study.Results:It was revealed that endotoxin challenge could markedly decrease intestinal transmucosal potential difference (ITPD) normal controls vs.endotoxic shock:(59 63±0 65)vs.(55 51±1 53)mV ,whereas rhubarb potentially improved ITPD (59 34±0 87)mV ,and the differences between two groups were significant.Following treatment with rhubarb,significant therapeutic effect was achieved in 30 out of 36 patients with stress ulcer complicated by gastrointestinal hemorrhage (only 6 patients with bleeding again).However,H 2receptor blocking agents had poor effect on those patients,and bleeding occurred again in all cases ( P <0 05).Among 49 cases of toxic paralytic ileus treated by rhubarb,peristalsis was recovered in 41 cases,and gastrointestinal essential nutrition (2 090 kJ/d) could be tolerated in 24 cases,while no such effect was found in 27 patients treated with H 2receptor blocking agents.Conclusions:The results suggest that rhubarb can increase excitability of gastrointestinal smooth muscle,promote intestinal peristalsis,and have good effects on stress ulcer.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第7期411-413,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金
