摘要
目的：对43例药物性肝病患者进行分析，以帮助临床医师对该病作出正确诊断和治疗。方法：根据服药史、临床症状、血象、肝功能试验、病原学标志，以及停药后的效应作出综合诊断。结果：引起肝病的有关药物中，性激素药占13．9％，抗炎药占11．6％，抗结核类药占9．3％，心血管类药占4．6％，抗精神失常药占4．6％，泻药占4．6％，磺胺类药占2.3％，抗震颤麻痹药占2．3％，中草药类占30．2％，其他类药物占16．2％。临床分类：41例急性药物性肝病，其中肝细胞损伤型31例，胆汁淤滞型8例，混合型2例。2例为慢性药物性肝病。结论：临床上一旦明确诊断，立即停用有关药物，预后良好，本组中无一例死亡。
Objectives: Frequently the liver becomes a target of drug toxicity and drug－induced liver disease account for considerable percentage in cases of jaundice and hepatitis. Methods: 43 cases with drug－induced liver damage adlnitted to our hospital from 1982 to 1995 were reviewed. Results: The etiological agents could be defined as follows: some herbal mallcine (30.2％), sex andanabolic steroids (13.9％), anti－innammatory agents (11.6％), anti－tuberculous trigs (9.3％),psychotropics (4.6％), cardiovascular drugs (4.6％), cathartics (4.6％), suharug (2.3％), anti－tumoragents (2.3％), and miscellahous (16.2M). Fourty one patients were presented as acute liver iniwr,among them, 31 were of hepatocellular type, 8 acute cholestatic and 2 mised type. One patient wascomplicated with acute liver failure, the other two patiente were of drinic onset, on. as chronic active hepatitis and another as chronic cholestasis. The prognbo of those patients were rather. good and all recovered uneventfully after proper treatthent. Conclusions: Discriminating drug－induced liver disease from other liver disease especially viral hepatitis is of hoportance in clinical practice.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1997年第2期88-90,共3页
Chinese Journal of Digestion
关键词
肝疾病
化学诱导
诊断
临床分析
Liver disease/chemically induced,liver disease/diagnosis disease/therapy
