期刊文献+

抗VEGF药物治疗新生血管性眼病的研究进展 被引量:11

Progress of researches on anti-VEGF medication for neovascular oculopathy
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摘要 血管内皮生长因子(vascular endothelial growth facto VEGF)是促成新生血管形成的重要诱生物,目前应用VEGF抑制剂治疗新生血管性眼病已受到越来越多的重视。本文对目前已经或者即将应用于眼科临床的药物,包括Macugen,Lucentis,Avastin,VEGF-trap的研究现状作一综述。 Vascular endothelial growth factor (VEGF) plays a critical role in inducing neovascularization. Nowadays, application of VEGF inhibitor to treatment of neovascular eye diseases has caught more and more attention. The present paper summarized the recent advance of these anti-VEGF agents which had been used or would be used in ophthalmologic clinic, including Macugen, Lucentis, Avastin, VEGF-trap and so on.
出处 《国际眼科杂志》 CAS 2008年第1期123-125,共3页 International Eye Science
关键词 血管内皮生长因子 抑制剂 新生血管性眼病 药物治疗 vascular endothelial growth factor inhibitor neovascular eye diseases
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参考文献20

  • 1Gragoudas ES,Adamis AP,Cunningham ET.Pegaptanib for neovascular age-related macular degeneration.N Engl J Med 2004;351:2805-2816
  • 2Brown GC,Brown MM,Brown HC,et al.A value-based medicine comparison of interventions for subfoveal neovascular macular degeneration.Ophthalmology 2007;114(6):1170-1178
  • 3Adamis AP,Altaweel M,Bressler NM,et al.Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals.Ophthalmology 2007;114(3):615-616
  • 4Cunningham ET,Adamis AP,Altaweel M,et al.A phase Ⅱ randomized double-masked trail of pegaptanib,an anti-vascular endothelial growth factor aptamer,for diabetic macular edema.Ophthalmology 2005;112(10):1747-1757
  • 5Sun Y,Jain A,Moshfeghi DM.Elevated vascular endothelial growth factor levels in Coats disease:rapid response to pegaptanib sodium.Graefes Arch Clin Exp Ophthalmol 2007;245(9):1387-1388
  • 6Presta LG,Chen H,O'Connor SJ,et al.Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.Cancer Res 1997;57:4593-4599
  • 7Rosenfeld PJ,Brown DM,Heier JS,et al.Ranibizumab for neovascular age-related macular degeneration.N Engl J Med 2006;355(14):1419-1431
  • 8Fung AE,Lalwani GA,Rosenfeld PJ,et al.An optical coherence tomography-guided,variable dosing regimen with intravitreal ranibizumab(Lucentis)for neovascular age-related macular degeneration.Am J Ophthalmol 2007;143(4):566-583
  • 9Rosenfeld PJ,Heier JS,Hantsbarger G,et al.Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucentis) for neovascular age-related macular degeneration.Ophthalmology 2006;113(4):632.e1
  • 10Brown DM,Kaiser PK,Michels M,et al.Ranibizumab versus verteporfin for neovascular age-related macular degeneration.N Engl J Med 2006;355(14):1432-1444

二级参考文献53

  • 1胡春玲,陈维,惠延年.早期糖尿病大鼠视网膜中MMP-3和VEGF表达的意义[J].国际眼科杂志,2004,4(4):615-617. 被引量:10
  • 2刘庆淮,谢平,戈应宾,袁孝如.糖尿病患者眼前房液血管内皮生长因子与转化生长因子β_2的变化[J].国际眼科杂志,2004,4(6):1015-1018. 被引量:9
  • 3蔡春梅,孙葆忱,刘旭阳.短发夹RNA对人视网膜色素上皮细胞血管内皮生长因子表达的抑制[J].中华眼科杂志,2006,42(4):334-337. 被引量:6
  • 4许建华,刘哲丽,李若溪,孔伟,张薇.曲安奈德对缺氧条件下恒河猴脉络膜视网膜内皮细胞VEGF表达的影响[J].国际眼科杂志,2006,6(5):1053-1055. 被引量:9
  • 5Singh N,Amin S,Richter E,Rashid S,Scoglietti V,Jani PD,Wang J,Kaur R,Ambati J,Dong Z,Ambati BK.Flt-1 Intraceptors Inhibit Hypoxia-Induced VEGF Expression In Vitro and Corneal Neovascularization In Vivo.Invest Ophthalmol Vis Sci,2005;46:1647-1652
  • 6Ideno J,Mizukami H,Kakehashi A.Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.Int J Mol Med,2007; 19(1):75-79
  • 7VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group; D'Amico DJ,Masonson HN,Patel M,Adamis AP,Cunningham ET Jr,Guyer DR,Katz B.Pegaptanib sodium for neovascular age-related macular degeneration:two-year safety results of the two prospective,multicenter,controlled clinical trials.Ophthalmology,2006;113(6):992-1001
  • 8Adamis AP,Altaweel M,Bressler NM,Cunningham ET Jr,Davis MD,Goldbaum M,Gonzales C,Guyer DR,Barrett K,Patel M; Macugen Diabetic Retinopathy Study Group.Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals.Ophthalmology,2006;113(1):23-28
  • 9Robinson GS,Pierce EA,Rook SL,Foley E,Webb R,Smith LE.Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy.Proc Natl Acad Sci USA,1996;93(10):4851-4856
  • 10Lai CM,Spilsbury K,Brankov M,Zaknich T,Rakoczy PE.Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA.Exp Eye Res,2002;75 (6):625 -634

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