摘要
目的:观察黑骨头乙醇提取物的抗炎镇痛作用。方法:采用二甲苯致小鼠耳廓肿胀、醋酸致小鼠腹腔毛细血管通透性增加模型观察黑骨头的抗炎作用;采用热板法、醋酸扭体法观察黑骨头的镇痛作用。结果:黑骨头可有效提高小鼠痛阈值(P<0.01)和抑制小鼠醋酸扭体反应率(P<0.05);对二甲苯所致小鼠耳肿胀有显著抑制作用(P<0.01);对醋酸所致小鼠腹腔毛细血管通透性增加也有抑制作用(P<0.05)。结论:黑骨头具有较好的抗炎、镇痛作用。
Objective:To observe the anti-inflammatory and analgesic effect of the alcohol extract of Periploca Forrestii Schlechter.Method:A hot-plate test and an acetic acid writhing method were used to make mouse models of auricular intumesce by dimethy-benezene and abdominal capillary permeability by acetic acid to observe the anti-inflammatory and analgesic effect of Periploca Forrestii Schlechter.Result:Periploca Forrestii Schlechter could raise the threshold value(P>0.05),inhibit the mice writhing reaction rate(P>0.05) and inhibit the mice auricular intumesce by dimethy-benezene obviously(P>0.01) and also inhibit the mice abdominal capillary permeability by acetic acid(P>0.05).Conclusion:Periploca Forrestii Schlechter has a better anti-inflammatory and analgesic effect.
出处
《云南中医中药杂志》
2008年第1期35-36,共2页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金
大理学院科研项目(编号:2006DX34)
关键词
黑骨头
抗炎
镇痛
实验研究
Periploca Forrestii Schlechter
anti-inflammatory and analgesic
experimental research
